New diseases and germs are emerging day by day in our world. But cancer is the most deadly disease that came many years. It is very sad that it could not be eradicated permanently till today. Cancer is caused by abnormal cell growth. As a result it is impossible to save the victim. So it is a life-killing disease. But many scientists are still struggling to find a cure for it. And many types of plants, fruits, vegetables are being researched to use the chemicals against cancer. In this study, explain the anticancer properties of a plant family known as Cucurbitacins. Estrogen signaling is crucial for carcinoma initiation and progression which stimulates estrogen receptor (ER) for proliferation leading to growth of estrogen-responsive tumors. Plant compounds like coumarins, cucurbitacins, flavonoids, alkaloids and flavonoids, etc...From different plant parts were used because the further alternative treatment of breast cancer. Among the compounds, cucurbitacins have shown promising results over the treatment. Cucurbitacins is a highly oxygenated tetracyclic triterpenoids species. These include the blockers of the JAK/STAT pathways. Now explain the chemical structure, physical properties, and the role of in vitro, in vivo, along with the in silico analysis shows that the estrogen receptor controls the proliferation of breast cancer cells.

Keywords : Cancer, Estrogen receptor, Cucurbitacins, JAK/STAT, MAPK and Proliferation.