Sepsis is an organ dysfunction because of
impaired regulation of the body's response to infection.
In non-cardiac ICU cases, sepsis is the second leading
cause of mortality. Because of the high mortality of
sepsis, the Surviving Sepsis Campaign (SSC) updated the
management of sepsis with the latest guidelines, namely
the one-hour bundle comprising an examination of
lactate levels, blood cultures, administration of broadspectrum antibiotics, crystalloids, and vasopressors. The
SSC guidelines also recommend that ScvO2 monitoring
can improve the prognosis of patients with septic shock.
One of the non-invasive tissue oxygenation monitoring
techniques is near-infrared spectroscopy (NIRS) which
can estimate cerebral oxygenation. The study stated that
the measurement of cerebral oxygen saturation (rSO2)
using NIRS correlated with ScvO2, where rSO2
correlates with ScvO2 in septic patients significantly.
Aim: To figure the description of cerebral oxygenation
after one-hour bundle administration in the
management of sepsis patients at Haji Adam Malik
General Hospital Medan.
Methods: This study is an analytic interventional study
to determine the description of cerebral oxygenation
after the one-hour bundle administration in septic
patients. After obtaining approval from the Ethics
Committee of the Faculty of Medicine, University of
North Sumatra, based on the inclusion and exclusion
criteria, we collect 30 research samples. The study
sample was all patients diagnosed with sepsis and treated
with one-hour bundle sepsis that met the inclusion and
Results: This study found that the mean value of SBP T0
is 88,03. The mean value of SBP T1 is 103. In DBP we
found that the mean value of DBP T0 is 55,27, while the
mean value of DBP T1 is 59,27. The mean value of HR
T0 is 117,57. Mean value of HR T1 is 110,87. In the
examination of rSO2, the mean value of right cerebral
oxygentation before and 1 hour after the administration
of the sepsis bundle are 46,5 and 49,76 and the mean
value of left cerebral oxygentation before and 1 hour
after the administration of the sepsis bundle are 46,76
dan 50,32 in an order. There was a significant difference
in the right rSO2 similar with the left rSO2 before and 1
hour after the administration of the sepsis bundle.
Keywords : Sepsis, rSO2, SBP, DBP, HR.