The Buschke-Löwenstein tumor is a rare tumor. It is a tumor linked to a sexually transmitted viral infection by the human papillomavirus (HPV) that develops on the external genitalia and the ano-rectal region. Objective: To describe the clinical, anatomopathological and management characteristics through a series of 18 observations in a North African population. Methods: We have retrospectively analyzed data from 18 patients in our prospective database since 2010. This work is based on the exploitation of clinical records, the interpretation of the radiological balance, the analysis of therapeutic methods, as well as short- and long-term developments. Results: This includes 18 men whose average age is 52.4 years, 12 of whom have risky sexual behaviors with two men who have sex with men (MSM), chronic smoking, cannabis addiction, and HIV-positive human immunodeficiency virus (HIV) for eight patients with Buschke-Lowenstein tumors treated with full surgical resection, which remains the reference treatment. All patients were sexually active. In all patients, the tumors were exophytic, cauliflower-shaped ulcers dotted with outbreaks of infection. Most of the shapes seen were bulky with an average size of 11cm. The location on the genital area was constant within 9 cases of an invasion on the thighs and the peri-anal region. No surgical complications were noted, particularly infectious. A relapse was noted in one patient, and it was treated with radiotherapy and surgical recovery. Due to its rarity, the management of this type of tumor remains uncodified and a multidisciplinary consultation meeting and network management in an expert center guarantee a better therapeutic strategy. Conclusions: There seems to be a consensus that the surgical option should be as radical as possible with organ preservation. Prevention of this tumor is based on the treatment of acuminate condylomas and the fight against sexually transmitted infections.

Keywords : Buschke-Lowenstein Tumor, Surgery, Human Papillomavirus, Radiotherapy, Relapse.