Design and Characterization of Bilayer Tablet of Rifampicin and Isoniazid for Tuberculosis Therapy

Authors : Dr. Subashini Rajaram, Dr. Senthil Rajan, B. Jamuna, V. Divya, P. Elango, M. Farheen Kausar, Gogineni Chandan

Volume/Issue : Volume 4 - 2019, Issue 9 - September

Google Scholar :

Scribd :

The present study aim was to formulate and evaluate the bilayer tablets containing Rifampicin immediate release layer (IR) and isoniazid in the sustained release (SR) layer in the way to develop a single tablet containing two different layers of drugs as widely used by physician and have better patient compliance. The SR layer of Isoniazid was developed by the method of wet granulation and using the grade of HPMCK100m, and other excipients like lactose, magnesium stearate, microcrystalline cellulose & talc. The IR layer of Rifampicin was developed by the method of direct compression. The powders are characterized by pre formulation properties and tablets are characterized by post formulation properties. The in-vitro study of Rifampicin and Isoniazid using USP(type 2) dissolution apparatus. The release rate studied for 45 mins by using 0.1M HCL and phosphate buffer PH 6.8 for 2hrs absorbed by UV spectrophotometry. Rifampicin release rate from the formulations was more than 80% at 45 min by adding HPMCK100m. Total three batches of each drug have been manufactured and developed stable formulation, the stability studies was complied as per International Conference of Harmonization guidelines.

Keywords : HPMC, IR,SR,ICH Guideline, UV Method , USP.


Paper Submission Last Date
30 - September - 2023

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.