Authors : Dr. D. Christopher Vimalson; Dr. M. Alagarraja; Dr. C. Vasanthi; M. Priyadharshini; S. Aravindh Rao.; T. Gowrishankar; K. Monica; B. Siva; K. Yuvarajan

Volume/Issue : Volume 10 - 2025, Issue 4 - April

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DOI : https://doi.org/10.38124/ijisrt/25apr859

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Abstract : Microbeads containing Metformin Hydrochloride were effectively developed using the ionotropic gelation technique, employing sodium alginate as the polymer matrix and calcium chloride (CaCl2) as the cross-linking agent. This study aimed to develop Metformin HCl microbeads for controlled drug release, improved therapeutic efficacy, and enhanced bioavailability. Microbeads encapsulating Metformin Hydrochloride were formulated through extruding a blend of sodium alginate and Metformin HCl through a 22-gauge needle was used to introduce the solution into a calcium chloride bath, initiating ionotropic gelation. The resulting microbeads were characterized for various physicochemical properties, including Product yield, active pharmaceutical ingredient (API) content, and drug release behavior under in vitro conditions. Preformulation studies characterized the drug, evaluating Sensory characteristics, melting point determination, solubility profile, bulk and tapped density measurements, flow property assessment via angle of repose, and structural analysis using FTIR spectroscopy. An analytical method using UV-visible spectroscopy at 234nm was developed for Metformin HCl quantification. The prepared microbeads exhibited [Insert key findings here, e.g., a spherical shape and a yield of X%]. Drug content analysis revealed [Insert drug content percentage here, e.g., a drug loading of Y%]. "In vitro drug release studies revealed a sustained release pattern of Metformin HCl, extending over a period of 12 hours, indicating the formulation's potential for prolonged therapeutic action. These results suggest that the ionotropic gelation method is a suitable technique for preparing Metformin HCl microbeads with controlled release characteristics; this could potentially enhance its therapeutic effectiveness and bioavailability. Additional research is needed to [Mention future research directions, e.g., investigate the in vivo performance of the microbeads].

Keywords : Metformin HCl, Microbeads, Ionotropic Gelation, Controlled Release.

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