Authors : Mohammed Fathi Ibrahim Madani; FathElrahman Mahdi Hassan Gameel; Mahdi H. A. Abdalla; Wala Eldin Osman Elradi; Ines Belaiba Aloulou; Mohamed M. Babeker

Volume/Issue : Volume 11 - 2026, Issue 9 - September

Google Scholar : https://tinyurl.com/48heybma

DOI : https://doi.org/10.38124/ijisrt/26sep240

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Background: The unchecked growth of immature blood cells in the bone marrow is the hallmark of acute leukemia, a potentially fatal hematologic cancer. The burden of acute leukemia is exacerbated in low-resource environments like Sudan by a lack of thorough cancer registries, regional healthcare inequities, and inadequate diagnostic skills. Meningioma 1 (MN1) overexpression (OE) is associated with the progression from myelodysplastic syndrome to acute myeloid leukemia (AML) and correlates with poor survival in AML patients. So this study conducted to detect the expression of MN1 among Sudanese patients diagnosed with AML.  Methodology: 100 AML patients recruited in this study, they were diagnosed with basic steps of diagnosis, which involved bone marrow, flow cytometer and complete blood count also conducted.MN1 detection was conducted through application of real time polymerase chain reaction (RT-PCR). Data analysis conducted by SPSS version 20.

Keywords : Meningioma 1, Real Time Polymerase Chain Reaction.

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