Detection of Interleukin 5 and 6 on Suspected Patients with Clinical Symptoms of Guttate Psoriasis


Authors : Anushiya Ahbiraami Letchumanan, Mohd Nazil Salleh, Rosmani Ismail, Chin Chien Yee.

Volume/Issue : Volume 4 - 2019, Issue 2 - February

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://goo.gl/Hsq3ME

Thomson Reuters ResearcherID : https://goo.gl/KTXLC3

Guttate Psoriasis is a second and third higher incident of skin disease influence on children and young adult with poor hygiene reported in Malaysia and the universe. In Malaysia, the diagnosis performed based on the clinical presentation and fewer studies are being conducted. In this study, we are investigating the presentations of Interleukin (IL) 5 and 6 levels, which act as a biomarker. The plasma samples collected from 46 hospitalised patients and two healthy controls with the age range of 1 to 12. The patients selected based on the clinical symptoms and readings of Differential Counts (DC) analysis. We analysed the plasma by using a quantitative Sandwich Enzyme Immunoassay method according to the manufacturer. Our findings show that levels of IL-5 and 6 classified into acute and chronic stages. Average readings of IL-5 and 6 were 0.121pg/mL and 0.061pg/mL. The IL-5 level increased by four folds than the controls; however, the IL-6 levels show infinite value on controls. In addition, data analysed by using T-Test and ANOVA. The study was significant in classifying the stages for Guttate Psoriasis. The DC analysis has a significant role in screening clinical symptoms of Guttate Psoriasis. It recommended for a diagnostic test since it has high sensitivity, specificity, and accuracy on detecting Guttate Psoriasis. They complimented it on the plasma in serology diagnosis when the clinical features and DC remain abnormal. Inconclusive measurement of cytokines was useful in diagnosis and it will perform further studies on a molecular level for the better prognosis.

Keywords : Cytokines; Guttate Psoriasis; Paediatric; Differential Counts.

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