Authors :
Dr. Godwill Agbon-Ojeme; Dr. Bodeno Ehis; Dr. Hendrith Esene; Dr. Zekeri Sule; Dr. Felix Otuomagie; Vincent Adam
Volume/Issue :
Volume 10 - 2025, Issue 10 - October
Google Scholar :
https://tinyurl.com/mv4kc3k2
Scribd :
https://tinyurl.com/2cb4fbkk
DOI :
https://doi.org/10.38124/ijisrt/25oct617
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Abstract :
Background:
Ectopic pregnancy is a life-threatening gynecological emergency and a significant cause of maternal morbidity and
mortality in the first trimester of pregnancy.
Objective
The aim of this study is to formulate a simple scoring system for the early presumptive diagnosis of ruptured ectopic
pregnancy to minimize delay in recognizing the condition to reduce the associated maternal morbidity and mortality
especially in the poorly resourced and low-income settings.
Methods
A retrospective study of all cases of ruptured ectopic pregnancies at Central Hospital Benin City, Edo State, Nigeria
from January 2021 to December 2023 were analyzed. Participants’ medical records were used to extract socio-demographic
characteristics, clinical presentation and management outcome data.
An acronym known as “PAPPA” was formulated from ‘pain’, the leading clinical features ‘pulse rate’, ‘adnexal
tenderness’, ‘palor’ and ‘amenorrhea’ in order from the highest frequencies, with two points given to each clinical feature
with a cumulative maximum score of 10. On the application of the PAPPA scoring parameter to the disease conditions that
mimic ruptured ectopic pregnancy, in respect to their common clinical features, the maximum score obtained was found to
be 6 points each. This meant that seven points could be taken as ‘discriminatory zone’ against these clinical differentials for
early presumptive diagnosis of ruptured ectopic pregnancy.
Results
There were sixty-nine (69) cases of ruptured ectopic pregnancies with an incidence of 3.4% of all gynecological
admissions and 0.65% of total number of deliveries. The mean age of occurrence was 27.3 years and 49.3% of these cases
were nulliparous. Five leading clinical features found to be present in the participants were identified: lower abdominal pain, adnexal tenderness, fast pulse rate, pallor and amenorrhea in frequencies of 100.0%, 100.0% 94.2%, 89.9% and 75.4%
respectively.
Conclusion
PAPPA scoring system is a useful tool which can increase the level of index of suspicion of ruptured ectopic pregnancy
with a pelvic ultrasound scan backup for definitive diagnosis when available. This will aid escalation of cases in order to
trigger early intervention and prevent maternal morbidities and mortalities.
Keywords :
Extra-Uterine Gestation, Presentation, Presumptive Diagnosis, Risk Factor, Ruptured Ectopic Pregnancy.
References :
- Paluku JL, Kalole BK, Furaha CM. Late abdominal pregnancy in a post-conflict context:case of a mistaken acute abdomen-a case report. BMC Pregnancy Childbirth. 2020;20(1):238.
- Meena N, Bairwa R, Sharma S. Study of ectopic pregnancy in a tertiary care centre. Int J Reprod Contracept Obstet Gynecol. 2019;9(1):212-5.
- Ectopic Pregnancy. Current Diagnosis and Treatment Obstetric and Gynaecology. 11th Edition Chapter 13, pages 242-249.
- Andrew Horne. Implantation and Early Pregnancy Loss. Gynaecology by Ten Teachers. 20th Edition Chapter 59 pgs. 59-67.
- Abdulkareem TA, Eldan SM. Ectopic pregnancy: diagnosis, prevention and management. Intech. 2017:49-65.
- Okoror CEM, Uhunmwangho BO, Idemudia O. Ectopic pregnancy at a teaching hospital, Nigeria: an analysis of presentation and risk factors. Menoufia Med J. 2020;33(2):415-8.
- Oguejiofor CB, Ezugwu CJ, Eleje GU, Emeka EA. Ruptured ectopic pregnancy in a nigerian tertiary hosiptal: what has changed? Int J Gynecol Obstetric Res. 2020; 8:14-9.
- Celestine OJ, Justina OA. Ectopic pregnancy experience in a tertiary health facility in South-South Nigeria. Niger Health J. 2016;16(1):56-78
- Zhang J, Zhang Y, Gan L, Liu X, Du S. Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy. BMC Pregnancy Childbirth. 2020;20(1):654.
- Collins Okror et al Ectopic Pregnancy at a Teaching Hospital in Nigeria: An Analysis of Presentation and Risk Factors, Menoufia Medical Jour. 2020;33(2)15-26.
- Agbon-Ojeme G, Benebo A., et al. Changing Proportions of Unusual Ectopic Pregnancy Sites. Tropical Journal of Obstetrics and Gynaecology Published Journal Gurus. 2023:41(20);20-27.
- Hendrick E. Rosenberg, R. Prine L. Ectopic Pregnancy: Diagnosis and Management Am. Fam, Physician. 2020:101(10):5990606.
- Eke E.O. Ekeleme C.N. Ezirim E.O. Onwuka JC, Eke. K.O. Ectopic Pregnancy Health Institution in Umuahia South East Nigeria. European Journal of Medical and Health Sciences 2022: 4: 1394.
- Ononuju CN, Adejo EO, Changkat LI, Okwaraoha BO, Uzoma EC. Ectopic pregnancy in Dalhatu Araf Specialist Hospital Lafia, Nigeria: A 5 – year review. Niger Postgrad Med J. 2019; 26(4): 235-238.
- Udigwe G.O. Uneomonhu, O.S., Mbachu I.I. Ectopic Pregnancy. A 5 Year review of Cases at Nnamdi Azikiwe Teaching Hospital Nnewi. Nig. Med. Jour. 2010:51:160-3.
- Yusif Y, Kofi SN, Osei FA, Odoom FSN. Ectopic pregnancies in low resource setting: A retrospective review of cases in Kumasi, Ghana. International Journal of Reproduction, Contraception, Obstetrics and Gynaecology. 2021; 10(4): 1278-1283.
- Iianjselvi M, Shobana KP. Prospective study on ectopic pregnancy in a tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynaecology. 2021; 10(5): 1889-1893.
Background:
Ectopic pregnancy is a life-threatening gynecological emergency and a significant cause of maternal morbidity and
mortality in the first trimester of pregnancy.
Objective
The aim of this study is to formulate a simple scoring system for the early presumptive diagnosis of ruptured ectopic
pregnancy to minimize delay in recognizing the condition to reduce the associated maternal morbidity and mortality
especially in the poorly resourced and low-income settings.
Methods
A retrospective study of all cases of ruptured ectopic pregnancies at Central Hospital Benin City, Edo State, Nigeria
from January 2021 to December 2023 were analyzed. Participants’ medical records were used to extract socio-demographic
characteristics, clinical presentation and management outcome data.
An acronym known as “PAPPA” was formulated from ‘pain’, the leading clinical features ‘pulse rate’, ‘adnexal
tenderness’, ‘palor’ and ‘amenorrhea’ in order from the highest frequencies, with two points given to each clinical feature
with a cumulative maximum score of 10. On the application of the PAPPA scoring parameter to the disease conditions that
mimic ruptured ectopic pregnancy, in respect to their common clinical features, the maximum score obtained was found to
be 6 points each. This meant that seven points could be taken as ‘discriminatory zone’ against these clinical differentials for
early presumptive diagnosis of ruptured ectopic pregnancy.
Results
There were sixty-nine (69) cases of ruptured ectopic pregnancies with an incidence of 3.4% of all gynecological
admissions and 0.65% of total number of deliveries. The mean age of occurrence was 27.3 years and 49.3% of these cases
were nulliparous. Five leading clinical features found to be present in the participants were identified: lower abdominal pain, adnexal tenderness, fast pulse rate, pallor and amenorrhea in frequencies of 100.0%, 100.0% 94.2%, 89.9% and 75.4%
respectively.
Conclusion
PAPPA scoring system is a useful tool which can increase the level of index of suspicion of ruptured ectopic pregnancy
with a pelvic ultrasound scan backup for definitive diagnosis when available. This will aid escalation of cases in order to
trigger early intervention and prevent maternal morbidities and mortalities.
Keywords :
Extra-Uterine Gestation, Presentation, Presumptive Diagnosis, Risk Factor, Ruptured Ectopic Pregnancy.