Development and Evaluation of a Novel Transungual Formulation (Nail Patch) for the Treatment of Onychomycosis

Authors : Samyuktha Metta, Dr. K.S .Murali Krishna, Swapna. Kandukuri, Sravya Maddukuri, Swarna Latha Nagadhani.

Volume/Issue : Volume 3 - 2018, Issue 6 - June

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The textile industry is one of the major contributor towards environmental pollution. The amount of effluent directly being disposed off into the water resources, causes hazardous diseases and various other effects in human beings. Various methodologies are adopted for the treatment of textile effluent like precipitation, absorption, adsorption, nanofiltration, flocculation etc. In this work titled “ TWO STAGE ADSORPTION PROCESS IN COLOUR REMOVAL OF CRYSTAL VIOLET DYE” we are performing a two stage consecutive process in the treatment of basic dye “Crystal Violet”. We have chosen adsorption process because of the simplicity and reliability of the process, it requires low energy and maintenance costs .The methodology consists of biosorption technique where we used rice husk as adsorbent and then followed by chemisorption technique for which we used zinc oxide nanoparticles, prepared by precipitation method. By varying the dosage, time, pH of the adsorbent the optimum optical density values were found using UV-VIS Spectrophotometer. The various characteristics of the treated sample were studied and reported. Significant changes in the colour removal of dye was observed and the maximum removal was found at 300ppm of concentration of dye, 0.8 gram of rice husk(biosorbent), 200 minutes of time , pH value of 6 and dosage of ZnO nanoparticles of 1 gram (chemisorbent). The experimental results show that these adsorbents have good potential to remove the colour from the effluent.

Keywords : Onychomycosis , Transungual, Permeation enhancers, Itraconazole, in-vitro permeation study.


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