A reservoir type transdermal film for delivery of Selegiline hydrochloride(SH)is a SSRI (selective serotonin reuptake inhibitors)agent with antidepressant activity and acts by inhibiting MAO type Binhibitor.Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of SH across cellophane/rat skin.Films were prepared by using hydroxy propyl methyl cellulose(HPMC), polyvinylalcohol (PVA) and methyl cellulose (MC) polymers by incorporating glycerine as plasticizers using solvent casting method. A total of eighteen formulations were prepared by using different drug polymer ratio of 1:1, 1:2 and 1:3 from these ratios 1:3 ratio of polymers is selected for incorporated terpenes as permeation enhancers in same concentrations. The maximum percent of drug permeation was observed with PVA monolithic transdermal film containing 5% eucalyptol (F12). The in vitro release studies revealed that eucalyptol showed better permeation enhancement than d limonene and menthol the release was sustained up to 24 h and it follows fist-order kinetics. The release flux of selegiline hydrochloride from different transdermal films prepared in the range of 0.114 to 0.036 μg/cm2/hr. All the films were found to be stable at 37°C and 45°C with respect to their
Keywords : Selegiline hydrochloride (SH), transdermal films, in-vitro release and in- vivo studies.