Authors : Ramya Kumari Kadagandla; Ranjith Kumar Kadagandla; Dr. Baswaraju Macha; ChandraPrakash Bayya; Swetha Malyala; Saritha Devi

Volume/Issue : Volume 11 - 2026, Issue 8 - August

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Google Scholar : https://tinyurl.com/2s7yeskc

DOI : https://doi.org/10.38124/ijisrt/26aug1079

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

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Abstract : metformin hydrochloride, ramipril, atorvastatin, and glimepiride were 100, 0.5, 2.0, and 0.2 µg/mL, respectively, while the corresponding limits of detection were 10 µg/mL, 20 ng/mL, 50 ng/mL, and 200 ng/mL. The proposed method was found to be rapid, sensitive, and suitable for the simultaneous determination of all four drugs. Therefore, it can be applied to the routine quality-control analysis of metformin hydrochloride, ramipril, atorvastatin, and glimepiride in bulk materials and combined pharmaceutical formulations.

Keywords : Metformin Hydrochloride; Ramipril; Atorvastatin; Glimepiride; Simultaneous Estimation; RP-HPLC; Method Validation.

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