Authors :
Dr. K M Khairul Alam; Tanbin Jahan Ferdousy
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/35r7xw99
DOI :
https://doi.org/10.5281/zenodo.8113095
Abstract :
Background:
Reversed-phase HPLC (RP-HPLC) is a prevalent
chromatographic technique in the pharmaceutical field.
At present, there is no pharmacopoeial method to
estimate Empagliflozin in Empagliflozin tablets,
although a number of Empagliflozin brands in tablet
forms are sold in local pharmacies. In this study, an RPHPLC method has been developed and validated for
estimation of Empagliflozin in Empagliflozin 10mg
tablets. The correlation coefficient was
found 0.999 that indicated the linearity of the proposed
method. Specificity and robustness of the method were
also confirmed. Conclusion:
The RP-HPLC method for estimation of
Empagliflozin in Empagliflozin tablet has been
developed and validated as per the ICH (International
Council for Harmonization of Technical Requirements
for Pharmaceuticals for Human Use) guidelines with
regard to the validation parameters.
Keywords :
Empagliflozin, RP-HPLC, Method Development, Validation, Tablet.
Background:
Reversed-phase HPLC (RP-HPLC) is a prevalent
chromatographic technique in the pharmaceutical field.
At present, there is no pharmacopoeial method to
estimate Empagliflozin in Empagliflozin tablets,
although a number of Empagliflozin brands in tablet
forms are sold in local pharmacies. In this study, an RPHPLC method has been developed and validated for
estimation of Empagliflozin in Empagliflozin 10mg
tablets. The correlation coefficient was
found 0.999 that indicated the linearity of the proposed
method. Specificity and robustness of the method were
also confirmed. Conclusion:
The RP-HPLC method for estimation of
Empagliflozin in Empagliflozin tablet has been
developed and validated as per the ICH (International
Council for Harmonization of Technical Requirements
for Pharmaceuticals for Human Use) guidelines with
regard to the validation parameters.
Keywords :
Empagliflozin, RP-HPLC, Method Development, Validation, Tablet.
