Authors :
Chidimma Nweke; Prema Kirubakaran; Ridwan Kolapo
Volume/Issue :
Volume 11 - 2026, Issue 8 - August
Google Scholar :
https://tinyurl.com/bdcu9jrc
Scribd :
https://tinyurl.com/5t4vz9da
DOI :
https://doi.org/10.38124/ijisrt/26aug048
Note : A published paper may take 4-5
working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and
ResearchGate.
Abstract :
Polycystic Ovary Syndrome (PCOS) is a lead major disorder and primary cause of infertility in women of
reproductive age, affecting about 13% of this population globally with over 70% of cases remaining undiagnosed. Early
diagnosis is yet challenging, particularly in low-resource settings where ultrasound imaging is inaccessible. This study
focuses on leveraging Random Forest (RF) model for PCOS prediction using only clinical and biochemical data, enhanced
with Shapley Additive Explanations (SHAP) for model interpretability. A publicly available Kaggle PCOS dataset from
541 women (177 PCOS-positive, 364 negative) across 10 hospitals in Kerala, India, was utilised. A leakage-free
preprocessing pipeline applied median and mode imputation before data splitting.
Keywords :
Polycystic Ovary Syndrome, Random Forest, Shapley Additive Explanations, Machine Learning, Explainable Artificial Intelligence, Clinical Diagnosis.
References :
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- World Health Organization, “Polycystic ovary syndrome”. Available at: https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome, 2025.
- I. Cicek, and Z. Kucukakcali, “Global interpretation of machine learning models in predicting polycystic ovary syndrome with the explainable artificial intelligence method SHAP,” Medicine Science | International Medical Journal, 2025, 13(3): 568-574.
- S. Mane, R. Aghav, and S. Karad, “PCOS Management: Integrating Contemporary Medicine and Lifestyle Interventions,” Himalayan Journal of Health Sciences, 2025, 10(1): 33-35.
- H.J. Teede, C.T. Tay, J. Laven, A. Dokras, L.J. Moran, T.T. Piltonen, M.F. Costello, J. Boivin, L.M. Redman, J.A. Boyle, R.J. Norman, A. Mousa, and A.E. Joham, “Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome,” Fertility and Sterility, 2025, 120(4): 767-793.
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- S. Yasar, “Machine Learning-Driven Metabolomic Biomarker Discovery for PCOS: An Interpretable Approach Using Random Forest and SHAP,” Medical Records, 2025, 7(3): 763-767.
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- Z. Zad, V.S. Jiang, A.T. Wolf, T. Wang, J.J. Cheng, I.C. Paschalidis, and S. Mahalingaiah, “Predicting polycystic ovary syndrome with machine learning algorithms from electronic health records,” Frontiers in Endocrinology, 2024, 15: 1298628.
- F.J. Barrera, E.D. Brown, A. Rojo, J. Obeso, H. Plata, E.P. Lincango, N. Terry, R. Rodriguez-Gutierrez, J.E. Hall, and S. Shekhar, “Application of machine learning and artificial intelligence in the diagnosis and classification of polycystic ovarian syndrome: A systematic review,” Frontiers in Endocrinology, 2023, 14: 1106625.
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- B. Panjwani, J. Yadav, V. Mohan, N. Agarwal, and S. Agarwal, “Optimized Machine Learning for the Early Detection of Polycystic Ovary Syndrome in Women,” Sensors, 2025, 25(4): 1166.
- J. Lim, J. Li, X. Feng, L. Feng, Y. Xia, X. Xiao, Y. Wang, and Z. Xu, “Machine learning classification of polycystic ovary syndrome based on radial pulse wave analysis. BMC Complementary Medicine and Therapies, 2023, 23(1): 409.
- H. Narni, V. Ananthasetty, and S. Jilani, “Development of a Preliminary Screening Tool for Predicting Polycystic Ovarian Syndrome using Machine Learning and Deep Learning Models with Non-Invasive Qualitative Features: A Case-control Study,” Journal of Clinical and Diagnostic Research, 2024, 18(12): KC06-KC10.
Polycystic Ovary Syndrome (PCOS) is a lead major disorder and primary cause of infertility in women of
reproductive age, affecting about 13% of this population globally with over 70% of cases remaining undiagnosed. Early
diagnosis is yet challenging, particularly in low-resource settings where ultrasound imaging is inaccessible. This study
focuses on leveraging Random Forest (RF) model for PCOS prediction using only clinical and biochemical data, enhanced
with Shapley Additive Explanations (SHAP) for model interpretability. A publicly available Kaggle PCOS dataset from
541 women (177 PCOS-positive, 364 negative) across 10 hospitals in Kerala, India, was utilised. A leakage-free
preprocessing pipeline applied median and mode imputation before data splitting.
Keywords :
Polycystic Ovary Syndrome, Random Forest, Shapley Additive Explanations, Machine Learning, Explainable Artificial Intelligence, Clinical Diagnosis.