Authors :
FeniVenawati
Volume/Issue :
Volume 7 - 2022, Issue 7 - July
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3RGzL0r
DOI :
https://doi.org/10.5281/zenodo.6850152
Abstract :
Brain consumes 20% of the total oxygen
within our body. The most of it used to produce ATP.
High consumption of oxygen and absence of oxygen
reserves will cause the cessation of active brain perfusion
in an unconscious state. If blood flow does not return
within 3-8 minutes, ATP reserves will decrease and
causing permanent cell damage. NIRS is a non-invasive
monitoring technique to measure cerebral oxygen
saturation, the product of this cerebral oximeter is
INVOS 4100. Dexmedetomidine (DEX) is a selective 2-
adrenoreceptor agonist that has sedation effect,
analgesics, anti-anxiety and sympathetic nervous
inhibition, DEX also has a neuroprotective effect by
producing 2 receptor that is mediated by tyrosine kinase
receptor. An increase in rSO2 was found after
administration of dexmedetomidine sedation. The
combination of dexmedetomidine and fentanyl was
found to have a good sedative effect and more controlled
hemodynamics in CPB surgery.
Methods: This study is an observational analytic study
with a prospective cohort design. The sample were
patients who were treated by ventilator on the ICU of
general hospital Haji Adam Malik Medan. This study
uses consecutive sampling technique to gain the total of
the sample. All of the sample will be given
dexmedetomidine and fentanyl then we will monitor the
sample every 6 hours for 24 hours then the data will be
analyzed.
Result: The result of the paired T-test and Wilcoxon test
are there is a significant difference between before and
Keywords :
Dexmedetomidine, Fentanyl, INVOS, oxygenation, combination.
Brain consumes 20% of the total oxygen
within our body. The most of it used to produce ATP.
High consumption of oxygen and absence of oxygen
reserves will cause the cessation of active brain perfusion
in an unconscious state. If blood flow does not return
within 3-8 minutes, ATP reserves will decrease and
causing permanent cell damage. NIRS is a non-invasive
monitoring technique to measure cerebral oxygen
saturation, the product of this cerebral oximeter is
INVOS 4100. Dexmedetomidine (DEX) is a selective 2-
adrenoreceptor agonist that has sedation effect,
analgesics, anti-anxiety and sympathetic nervous
inhibition, DEX also has a neuroprotective effect by
producing 2 receptor that is mediated by tyrosine kinase
receptor. An increase in rSO2 was found after
administration of dexmedetomidine sedation. The
combination of dexmedetomidine and fentanyl was
found to have a good sedative effect and more controlled
hemodynamics in CPB surgery.
Methods: This study is an observational analytic study
with a prospective cohort design. The sample were
patients who were treated by ventilator on the ICU of
general hospital Haji Adam Malik Medan. This study
uses consecutive sampling technique to gain the total of
the sample. All of the sample will be given
dexmedetomidine and fentanyl then we will monitor the
sample every 6 hours for 24 hours then the data will be
analyzed.
Result: The result of the paired T-test and Wilcoxon test
are there is a significant difference between before and
Keywords :
Dexmedetomidine, Fentanyl, INVOS, oxygenation, combination.
