The study aimed to determine the level of academic performance in General Chemistry using differentiated instruction. The quasi-experimental design was utilized and data were treated using mean and standard deviation, t-test for dependent sample and t-test for independent sample. The salient findings revealed that the level of academic performance of participants in Chemistry before instruction in experimental and control group was failed. After instruction in experimental and control group got the passing grade while experimental group got highly satisfactory. There was a significant differences in the pretest to the posttest in the experimental and control group in terms of their academic performance in Chemistry. The study concluded that the use of instructional material has enhanced the students level of achievement in Chemistry.

Keywords : Chemistry, Teachers, Students, Instruction, Academic