Disease Prediction utilizing Machine Learning is a framework which predicts the infection dependent on the data or the indications he/she go into the framework and gives the exact outcomes dependent on that data. In the event that the patient isn't a lot of genuine and the client simply needs to know the kind of infection, he/she has experienced. It is a framework which gives the client the tips and deceives to keep up the wellbeing arrangement of the client and it gives an approach to discover the sickness utilizing this forecast. Presently a day's wellbeing industry assumes significant part in restoring the infections of the patients so this is additionally some sort of help for the wellbeing business to tell the client and furthermore it is valuable for the client in the event that he/she would not like to go to the clinic or some other centers, so by entering the manifestations and any remaining helpful data the client can become acquainted with the illness he/she is experiencing and the wellbeing business can likewise get advantage from this framework simply by asking the indications from the client and entering in the framework and in only couple of moments they can advise the specific and dependent upon some degree the precise sicknesses. This Disease Prediction Using Machine Learning is totally finished with the assistance of Machine Learning and Python Programming language with Tkinter Interface for it and furthermore utilizing the dataset that is accessible beforehand by the emergency clinics utilizing that we will anticipate the illness.