Authors :
Nnamani Onyinye Esther; Ukoha Ukoha; Ofoego U.C.
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
DOI :
https://doi.org/10.5281/zenodo.7439854
Abstract :
The use of polyphenols, as natural
antioxidants, are gaining importance, due to their health
benefits for humans, decreasing the risk of liver disease,
inflammation, cardiovascular and degenerative diseases
by reduction of oxidative stress and counteraction of
macromolecular oxidation. Although acetaminophen is
the most widely used painkilling and antipyretic, high
intake or consistent use of paracetamol have been
associated to a well-known contrary effect which includes
nephrotoxicity, hepatotoxicity (Olaleye and Rocha, 2008).
Experimental animals were randomly allocated into six
groups; A, B, C, D, E, F of six animals per group (n=6).
Group A was the control group and received only
standard diet animal feeds and distilled water only.
Group B received 4ml/kg body weight of fresh Citrullus
lanatus juice only for 28days. Group C received feed and
water for 28 days, and was treated only with 2g/ kg of
acetaminophen on the 29th and 31th day. Group D received
4ml/kg body weight of Citrullus lanatus juice for 28 days,
and was treated with single oral dose of 2g/ kg of
acetaminophen, on the 29th day. Group E and F received
2ml/kg and 4ml/kg body weight of fresh Citrullus lanatus
juice respectively for 28days, and was treated with 2g/ kg
body weight of acetaminophen on the 29th and 31th day. At
the end of the experiment, the Wistar was sacrificed and
organs collected for analysis. The results of our study
suggest that watermelon juice pretreatment boosted
antioxidant status and offered some protection against
high doses of acetaminophen induced injury in Wister
rat’s testes.
Keywords :
Testis, Citrulline Lunatus, Acetaminophen And Watermelon Juice
The use of polyphenols, as natural
antioxidants, are gaining importance, due to their health
benefits for humans, decreasing the risk of liver disease,
inflammation, cardiovascular and degenerative diseases
by reduction of oxidative stress and counteraction of
macromolecular oxidation. Although acetaminophen is
the most widely used painkilling and antipyretic, high
intake or consistent use of paracetamol have been
associated to a well-known contrary effect which includes
nephrotoxicity, hepatotoxicity (Olaleye and Rocha, 2008).
Experimental animals were randomly allocated into six
groups; A, B, C, D, E, F of six animals per group (n=6).
Group A was the control group and received only
standard diet animal feeds and distilled water only.
Group B received 4ml/kg body weight of fresh Citrullus
lanatus juice only for 28days. Group C received feed and
water for 28 days, and was treated only with 2g/ kg of
acetaminophen on the 29th and 31th day. Group D received
4ml/kg body weight of Citrullus lanatus juice for 28 days,
and was treated with single oral dose of 2g/ kg of
acetaminophen, on the 29th day. Group E and F received
2ml/kg and 4ml/kg body weight of fresh Citrullus lanatus
juice respectively for 28days, and was treated with 2g/ kg
body weight of acetaminophen on the 29th and 31th day. At
the end of the experiment, the Wistar was sacrificed and
organs collected for analysis. The results of our study
suggest that watermelon juice pretreatment boosted
antioxidant status and offered some protection against
high doses of acetaminophen induced injury in Wister
rat’s testes.
Keywords :
Testis, Citrulline Lunatus, Acetaminophen And Watermelon Juice
