Authors :
Aishwaryav; A. P. Nishad Begum
Volume/Issue :
Volume 11 - 2026, Issue 1 - January
Google Scholar :
https://tinyurl.com/yc5yv78z
Scribd :
https://tinyurl.com/ywh8tkmd
DOI :
https://doi.org/10.38124/ijisrt/26jan799
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background: International Journal of Innovative Science and Research Technology https://doi.org/10.38124/ijisrt/26jan799 ABSTRACT Diabetes can affect the tear film due to chronic hyper glycemia and reduced corneal sensitivity, leading to dry eye symptoms. Poor glycemic control and longer duration of diabetes further worsen tear quantity and quality. Assessing tear film changes helps in early detection and better ocular management in diabetic patients. Aim: To evaluate tear film quantity and quality in diabetic patients compared to non-diabetics, with reference to duration of diabetes. Methodology: This comparative study was conducted at Shridevi Institute of Allied Health Sciences from March to November 2025, including 56 participants—28 diabetics and 28 age-matched non-diabetic controls selected through systematic random sampling. After consent, each subject underwent Schirmer’s test, TBUT, and fluorescein staining to assess tear film quantity and quality. Results were compared between diabetic groups based on HbA1c and duration, and with nondiabetic control. Result: Diabetic participants showed significantly lower Schirmer’s and TBUT values compared to non-diabetics, indicating reduced tear quantity and stability. Higher HbA1c levels were associated with poorer tear film function, showing that diabetes negatively affects the tear film. Conclusion: Diabetes significantly reduces tear film quantity and stability, increasing the risk of dry eye. Poor glycemic control further worsens these changes, highlighting the need for regular tear film quantity and quality evaluation in diabetic patients.
Keywords :
Diabetes Mellitus, Glycemic Control, HbA1c, Tear Film, Schirmer’s Test, Tbut, Fluorescein Staining, Dry Eye.
References :
- Meng F, Zhou Y, Bao T, et al. Impact of hyperglycemia on tear film and meibomian gland dysfunction: a cross-sectional study. Diabetes Metab Syndr Obes. 2025;18:327–333. doi:10.2147/DMSO.S500595
- Khan, B., Rahil, N., Idris, M., Malik, A., Ali, R., & Israr, M. (2025). Comparative analysis of dry eye syndrome among diabetic versus nondiabetic patients presenting to a tertiary care hospital, Peshawar. Insights–Journal of Health and Rehabilitation, 3(3), 514–519. https://doi.org/10.xxxxxx/insights.jhr.2025.00303.
- Hada Y, Banait S. A comparative clinical study of the precorneal tear film in diabetic and nondiabetic persons. J Datta Meghe Inst Med Sci Univ 2019;14:342-5.
- Selvaraj V, Charumathi A, Iyyamma B, Anbunilavan. Comparative study of dry eye status in normal healthy individual and type-II diabetes mellitus. In: Futuristic Trends in Medical Sciences. 2023; Vol. 3, Book 9, Part 1, Chapter 34. p. 253–261. e-ISBN: 978-93-6252-809-4.
- Kuo, Y.-K., Shao, S.-C., Lin, E.-T., Pan, L.-Y., Yeung, L., & Sun, C.-C. (2022). Tear function in patients with diabetes mellitus: A systematic review and meta-analysis. Frontiers in Endocrinology, 13, 1036002. https://doi.org/10.3389/fendo.2022.1036002
- Desai, R., & Champaneria, D. (2021). A Comparative Study of Tear Film Tests in Diabetic and Non-diabetic Patients: A Cross-Sectional Study. Gujarat Medical Journal, 76(2), 31-37.
- AljAroushA M, Badarudin NE, Che Azemin MZ. Comparison of dry eye parameters between diabetics and non-diabetics in district of Kuantan, Pahang. Malays J Med Sci. 2016 May-Jun;23(3):72–7.
- AK Khurana, Aruj K Khurana and Bhawna Khurana. Comprehensive Ophthalmology. 6th Edition. The Health Sciences Publisher: Jaypee Brothers Medical Publishers; 2015;(4):45-47.
- Sudha R, Praveen Kumar KV. A clinical study of the pre-corneal tear film in diabetic and non-diabetic persons – a case control study. Indian J Clin Exp Ophthalmol. 2018;4(3):401- 405. doi:10.18231/2395-1451.2018.0087.
- Pai Shobha G, Pai Sheila R, Kini Jyoti, Nayak Madhurima K, Pai G Ajay. A comparative study of tear film function and tear secretion among diabetics. International Journal of Bioassays, 2014; 3(09): 3291-3296. http://www.ijbio.com/articles/a-comparative-study-of- tear-film-function-and-tear-secretion-among-diabetics.pdf.
- Zeng X, Lv Y, Gu Z, Jia Z, Zhang C, Lu X, Chu C, Gao Y, Nie Y, Wang Y, Zhang Y, Zhao S. The effects of diabetic duration on lacrimal functional unit in patients with type II diabetes. J Ophthalmol. 2019;2019:8127515. doi: 10.1155/2019/8127515. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350560/
- Xuan A, Zhang Z, Li Q, Li W, Pazo E, Li F, Huang Y, Yang R, Liu H, Li X, Zhao S, Zhang C. The impact of glycemic control and duration of diabetes on clinical manifestation of ocular surface in middle-aged and elderly type 2 diabetic population. Research Square; [preprint] 2023 :https://www.researchsquare.com/
- Wu H, Fang X, Luo S, Shang X, Xie Z, Dong N, Xiao X, Lin Z, Liu Z. Meibomian glands and tear film findings in type 2 diabetic patients: A cross-sectional study. Front Med (Lausanne). 2022;9:https://www.frontiersin.org/articles/10.3389/fmed.2022.762493/full
- Priya SV, Kumar N, Challa J, Anusha GL, Keerthi Sri AS, Farhad U. A comparative study of dry eye in diabetic and non-diabetic patients reported to ophthalmology OPD AIMSR, Chittoor, Andhra Pradesh. Int J Med Sci Clin Res Rev. 2022;5(05):631-635. doi:10.5281/zenodo.7105452: https://doi.org/10.5281/zenodo.7105452
- Varshney AS, Saraiya A B, Mahida H B, Patel C S, Chauhan M D. Impact of diabetes mellitus on tear secretion, intraocular pressure, and contrast sensitivity: A comparative study of controlled and uncontrolled diabetics. IP Int J Ocul Oncol Oculoplasty. 2024;10(4):179– 184: https://www.ijooo.org
- Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends. J Epidemiol Glob Health. 2020;10(1):107–111.
- Dai S, Long H, Wen J, Zhang L, Chen B. Alleviative effect of probiotics and prebiotics on dry eye in type 2 diabetic patients. Curr Eye Res. 2020;45(3):244–60.
- Vinker S. Dry Eye in Diabetic Patients. Am J Ophthalmol. 2005;139:498–503.
- Manaviat MR, Rashidi M, Afkhami-Ardekani M, Shoja MR. Prevalence of Dry Eye Syndrome and Diabetic Retinopathy in Type 2 Diabetic Patients. BMC Ophthalmology. 2008;8:10.
- Dogru M, Katakami C, Inoue M.Tear Function and Ocular Surface Changes in Non- Insulin-Dependent Diabetes Mellitus .Ophthalmology. 2001;108:586–
Background: International Journal of Innovative Science and Research Technology https://doi.org/10.38124/ijisrt/26jan799 ABSTRACT Diabetes can affect the tear film due to chronic hyper glycemia and reduced corneal sensitivity, leading to dry eye symptoms. Poor glycemic control and longer duration of diabetes further worsen tear quantity and quality. Assessing tear film changes helps in early detection and better ocular management in diabetic patients. Aim: To evaluate tear film quantity and quality in diabetic patients compared to non-diabetics, with reference to duration of diabetes. Methodology: This comparative study was conducted at Shridevi Institute of Allied Health Sciences from March to November 2025, including 56 participants—28 diabetics and 28 age-matched non-diabetic controls selected through systematic random sampling. After consent, each subject underwent Schirmer’s test, TBUT, and fluorescein staining to assess tear film quantity and quality. Results were compared between diabetic groups based on HbA1c and duration, and with nondiabetic control. Result: Diabetic participants showed significantly lower Schirmer’s and TBUT values compared to non-diabetics, indicating reduced tear quantity and stability. Higher HbA1c levels were associated with poorer tear film function, showing that diabetes negatively affects the tear film. Conclusion: Diabetes significantly reduces tear film quantity and stability, increasing the risk of dry eye. Poor glycemic control further worsens these changes, highlighting the need for regular tear film quantity and quality evaluation in diabetic patients.
Keywords :
Diabetes Mellitus, Glycemic Control, HbA1c, Tear Film, Schirmer’s Test, Tbut, Fluorescein Staining, Dry Eye.