Effect of Kenikir (Cosmos Caudatus) on Malondialdehyde (MDA) and Blood Pressure When Hypertension in Pregnancy : A Systematic Review


Authors : Diyas Windarena; Donny Kristanto Mulyantoro; Diyah Fatmasari

Volume/Issue : Volume 5 - 2020, Issue 9 - September

Google Scholar : http://bitly.ws/9nMw

Scribd : https://bit.ly/3nQVxjo

Hypertension in pregnancy is one of the causes of morbidity and mortality for pregnant women and babies. In a hypertensive state during pregnancy, there is oxidative stress which can be identified by checking the levels of malondialdehyde (MDA). Oxidative stress increases the complications of hypertension in pregnancy. Oxidative stress is characterized by a decrease in endogenous antioxidants, so to increase antioxidant levels in the body it is necessary to consume exogenous antioxidants, for example quercetin. The main flavonoids component of Kenikir (Cosmos Caudatus) is quercetin. The purpose of this systematic review is to analyze the effect of Kenikir (Cosmos Caudatus) or quercetin as the main flavonoid component of Kenikir on malondialdehyde (MDA) levels and blood pressure in hypertension in pregnancy through the results of previous research. The method used is PRISMA. Literature search using the database PubMed, cochrane, ScienceDirect, google scholar and DOAJ with the same keywords and published in 2015 - 2020. The literature search was conducted in May-June 2020. The results obtained 25 studies that met the inclusion criteria. The results showed that the extract of Kenikir (Cosmos Caudatus) contained quercetin 2.186 g / 100g. From the article review, it was found that Kenikir or quercetin as a flavonoid component of Kenikir can reduce levels of malondialdehyde (MDA) between 4.85- 170 nmol / ml and reduce blood pressure between 3 - 38.3 mmHg. There are 3 articles that show insignificant results in lowering blood pressure. So it can be concluded that Kenikir's active compound, quercetin, can reduce levels of malondialdehyde (MDA) and has the potential to lower blood pressure when Hypertension in pregnancy.

Keywords : Cosmos Caudatus, Blood pressure, malondialdehyde.

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