Authors :
Shaikh Nabila Jaan Mohammed; Dr. Vaishali Kale
Volume/Issue :
Volume 10 - 2025, Issue 9 - September
Google Scholar :
https://tinyurl.com/2t29rbfc
Scribd :
https://tinyurl.com/y7x6m4ud
DOI :
https://doi.org/10.38124/ijisrt/25sep1202
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Introduction:
The thoracic spine, consisting of twelve vertebrae (T1–T12), plays a crucial role in spinal stability and autonomic
nervous system function. T4 syndrome, a dysfunction localized at the T4 vertebral level, presents with a combination of
musculoskeletal and autonomic symptoms, including upper limb paresthesia, thoracic stiffness, and sympathetic nervous
system disturbances. Although the exact pathophysiology is unclear, mechanical irritation of the sympathetic chain by
hypomobile thoracic joints is hypothesized to contribute to symptom development.
Methods:
50 participants aged 18 to 50 years with a clinical diagnosis of T4 syndrome were selected for the study. The participants
were randomly divided into two groups of 25 each. Group A received mobilization therapy daily for one week, while Group
B received screw thrust mobilization therapy on alternate days over the course of one week.
Results:
Both interventions resulted in statistically significant improvements across all measured outcomes. In Group A
(mobilization), VAS scores decreased by 4.40 points (p < 0.0001), flexion and extension ROM increased by 0.464 and 0.368
units, respectively (p < 0.0001), and PSFS scores improved by 2.86 points (p < 0.0001). In Group B (screw thrust), VAS scores
decreased by 3.76 points (p < 0.0001), with flexion and extension gains of 0.468 and 0.228 units, respectively, and PSFS scores
increased by 2.40 points (p < 0.0001). Although mobilisation showed slightly greater improvements in pain reduction, flexion
ROM, and functional ability, the differences were not statistically significant, except for thoracic extension ROM, where
mobilisation significantly outperformed screw thrust (p = 0.0087).
Conclusion:
Both mobilisation and screw thrust mobilization techniques are effective in reducing pain, improving thoracic mobility,
and enhancing functional activity in patients with T4 Syndrome. Mobilization demonstrated slightly greater clinical benefits,
particularly in thoracic extension. These findings support the use of manual therapy as a primary intervention for managing
T4 Syndrome and emphasize the need for further research to explore long-term outcomes and autonomic nervous system
modulation.
Keywords :
T4 Syndrome, Mobilisation, Screw Thrust Mobilisation.
References :
- D. B. Chaurasia, Human Anatomy upper limb throx, satish kumar jain, 2016.
- J. A. Waxenbaum, V. Reddy and B. Futterman., “Anatomy, Back, Thoracic Vertebrae,” 1 august 2023.
- R. L. D. ... A. W. V. ... A. W. M.., GRAY'S ANATOMY, 2015.
- C. C. ... N., M. D. Pamela K. Levagie, Joint Structure and Function, Jaypee Brothers Medical Publisher, 2019.
- S. M. K. Grija Murugan, “Effectiveness of Thoracic Screw Thrust technique in T4 Syndrome,” 2 April - June 2018.
- P. Evans, “The T4 Syndrome Some Basic Science Aspects,” April 1997.
- J. B. L. A. C. Carolyn Kisner, Therapeutic Exercise, Jaypee Brothers Medical, 2023.
- E. Hengeveld, MAITLAND'S Verterbral Manipulation, 2014.
- A. P. therapy, “definition of mobilization”.
- A. P. Steve Karas, “T4 Syndrome,” 14 january 2015.
- Magee, D. j. (2008). orthopedic physical assesment. new Delhi.
- Joshua A Cleland, p. g. (2007, april 1). short term effects of thrust versus nonthrust moblilzation directed at the thoracic spin in patient with neck pain.
- Madelyn johnson, M. ... (2021, dec 9). Interrater relilbility of spine range of motion measurement using a tape measure and goniometer.
- Rob sillevis, j. c. (2010, dec 18). immediate effect of thoracic spine thrust manipulation on the autonomic nervous system.
- Seong rae yang, k. k. (2015, dec 27). the effect of thoracic spine mobilization and stabilization exercise on the muscular strength and flexibility of the trunk of chronic low back pain patients.
- wu, y.-t. s. (2018, april 17). the visual analog scale for rating, ranking and paired -comparison. a new technique for psychological measurment.
- Paul Nicholas, C. H. (2012, Aug 20). The use of the patient specific functional scale to measure rehabilitative progress a physiotherapy setting.
- T4 Syndrome: A Scoping Review of the Literature Karas, Steve et al. Journal of Manipulative & Physiological Therapeutics, Volume 40, Issue 2, 118 - 125
- T4 syndrome – A distinct theoretical concept or elusive clinical entity? A case report Hirai, Patricia Miyuki et al. Journal of Bodywork and Movement Therapies, Volume 20, Issue 4, 722 – 727
- Clinical Presentation, Quantitative Sensory Testing, and Therapy of 2 Patients with Fourth Thoracic Syndrome Mellick, Gary A. et al. Journal of Manipulative & Physiological Therapeutics, Volume 29, Issue 5, 403 – 40
- Jenny Louise Conroy, A. G. (2005, November). The T4 Syndrome. 10(4), pp. 292 - 296.
- wang, T. (2022, june 1). validity of the spurling test in the diagnosis of the case of cervical radiculopathy.
- samir henni, j. h. (2019, feb 21). microvascular response to the roos test has excellent feasibility and good reliability in patients with suspected thoracic outlet syndrome.
- reliability and validity of visual estimation in determining thorax roatation mobility using the quadruped lumbar locked position. (2024, may 01).
- Dutton, M. (2020). Dutton,s Orthopaedic Examination,And Intervention.
Introduction:
The thoracic spine, consisting of twelve vertebrae (T1–T12), plays a crucial role in spinal stability and autonomic
nervous system function. T4 syndrome, a dysfunction localized at the T4 vertebral level, presents with a combination of
musculoskeletal and autonomic symptoms, including upper limb paresthesia, thoracic stiffness, and sympathetic nervous
system disturbances. Although the exact pathophysiology is unclear, mechanical irritation of the sympathetic chain by
hypomobile thoracic joints is hypothesized to contribute to symptom development.
Methods:
50 participants aged 18 to 50 years with a clinical diagnosis of T4 syndrome were selected for the study. The participants
were randomly divided into two groups of 25 each. Group A received mobilization therapy daily for one week, while Group
B received screw thrust mobilization therapy on alternate days over the course of one week.
Results:
Both interventions resulted in statistically significant improvements across all measured outcomes. In Group A
(mobilization), VAS scores decreased by 4.40 points (p < 0.0001), flexion and extension ROM increased by 0.464 and 0.368
units, respectively (p < 0.0001), and PSFS scores improved by 2.86 points (p < 0.0001). In Group B (screw thrust), VAS scores
decreased by 3.76 points (p < 0.0001), with flexion and extension gains of 0.468 and 0.228 units, respectively, and PSFS scores
increased by 2.40 points (p < 0.0001). Although mobilisation showed slightly greater improvements in pain reduction, flexion
ROM, and functional ability, the differences were not statistically significant, except for thoracic extension ROM, where
mobilisation significantly outperformed screw thrust (p = 0.0087).
Conclusion:
Both mobilisation and screw thrust mobilization techniques are effective in reducing pain, improving thoracic mobility,
and enhancing functional activity in patients with T4 Syndrome. Mobilization demonstrated slightly greater clinical benefits,
particularly in thoracic extension. These findings support the use of manual therapy as a primary intervention for managing
T4 Syndrome and emphasize the need for further research to explore long-term outcomes and autonomic nervous system
modulation.
Keywords :
T4 Syndrome, Mobilisation, Screw Thrust Mobilisation.