Effect of some Plant Leaves Extracts on Weight, Neutrophil and Lymphocyte Constituents of Cyclophosphamide-Induced Anaemia in Adult Male Albino Rats


Authors : Dele-Olawumi Bukola; Olanrewaju, O.I; Ayodeji, P.A; Adedayo, E.O

Volume/Issue : Volume 5 - 2020, Issue 6 - June

Google Scholar : http://bitly.ws/9nMw

Scribd : https://bit.ly/3imuqd9

DOI : 10.38124/IJISRT20JUN630

Anaemia is a global public health problem, it is the most common disorder of the blood, affecting about a quarter of the people globally. The effect of Sorghum bicolor, Carica papaya and Hibiscus sabdariffa leaves extracts on weight, Neutrophil and Lymphocyte Constituents of Cyclophosphamide-induced Anaemia in adult male albino rats was investigated. Aqueous extracts of Five hundred grams (500g) of each of the pulverized leaves was obtained in each case. Forty non-drug treatment (40) adult male albino rats were randomly allotted to eight (8) groups of five rats each on the basis of body weight and their differences in weights did not exceed 5g. Anaemia was induced in the rats using Cyclophosphamide. Blood samples were collected from the rats for biochemical analysis. Hematological indices were determined using standard procedure. One-way analysis of variance (ANOVA) and Duncan Studentised New Multiple Range Test were used to separate and compare means. The differences in means were considered significant at 5% probability. The group treated with 400mg/kgbw Sorghum bicolor showed highest decrease (28.23%) in neutrophils. Similarly, the group treated with 400mg/kgbw Sorghum bicolor had the highest increase in lymphocytes (105.41%) compared to others. Sorghum bicolor was significantly (P<0.05) higher in of zinc, magnesium, manganese and phosphorus while Hibiscus sabdariffa has the highest content of iron This study demonstrated that Sorghum bicolor, Carica papaya and Hibiscus sabdariffa leaf extracts would be beneficial in boosting blood volume and presents alternative to low cost management of nutritional Anaemia.

Keywords : Plant Leaves, Neutrophil, Lymphocyte, Anaemia, Albino Rats, Cyclophosphamide.

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