The antiviral effect of Azithromycin has an action of large spectrum antiviral activity. Azithromycin will reduce the virus entry into the cells and also enhance the immune response against viruses. Azithromycin plays an important role in infection control such as sore throat, pneumonia, acute respiratory syndrome. To determine the effectiveness of Azithromycin in the treatment of COVID-19 and its safety as an antiviral therapeutic agent. A literature search was done based using the search keywords ( COVID-19 OR coronavirus 2019) AND (Azithromycin) AND (Treatment). Randomised controlled trials investigating the effect of Azithromycin and safe during the period of hospitalisation in the treatment of COVID 19 and further followed by Cochrane database bias assessment was done. Four randomised controlled trials were included. The usage of Azithromycin, in maintaining the optimal range of respiratory rate, throughout the entire duration of stay of the patients, during hospitalization, were statistically significant when it is used along with Hydroxychloroquine. The study concludes that Azithromycin, when used along with Hydroxychloroquine, controls the infection in COVID-19.

Keywords : COVID-19 ( coronavirus 2019), Azithromycin, treatment.