A structured clinical mentorship program built into the hospital policy will facilitate easy transition of a novice nurse to a competent nurse. This study aimed to assess the effectiveness of a structured Clinical Mentorship program on confidence levels of nurses with less than one year of experience. An Evaluative Research approach with repeated measures design was used. Eighty-Eight Nurses with less than one year of experience (Mentees) were recruited for study through random sampling. After matching with a Mentor, a New Nurse Confidence Scale was used to assess the confidence levels before intervention and at 6 months and 12 months of intervention. The intervention was a Structured Clinical Mentorship Program which included individual mentoring for the nurses by trained mentors. The confidence Mean was 48.69(SD+/-5.06) before intervention, 57.77(SD+/-3.23) at 6 months and 51.28(SD+/-7.88) at 12 months after intervention. Repeated measures ANOVA revealed that there was very high level of statistical significance between pre and post-test assessment at 6 months at P=0.001 and 12 months at P=0.013 level indicating that the Clinical Mentorship Program had significant impact on the confidence levels of the Mentees. There was significant improvement in the confidence levels of novice nurses after the Clinical Mentorship Program. An effective mentoring program supports beginner nurses, provides them with sufficient opportunities to learn from experienced nurses and thus enhances their self-confidence.