Administration of intravenous lidocaine as an
adjunct to placebo in postoperative pain is highly
recommended. Its use has been proven safe and effective
in mastectomy surgery.
To determine the effectiveness of bolus
administration of continuous intravenous lidocaine on
pain intensity after mastectomy surgery at Haji Adam
Malik General Hospital of Medan and North Sumatra
This research is a randomized controlled and
double-blind clinical trial. It was conducted for 2 months
in November-December 2019. The total sample obtained
was 42 patients. This sample was divided into 2 groups:
group A (lidocaine) and group B (placebo). Data was
collected using the VAS questionnaire at hours 0 (T0), 2
(T1), 4 (T2) and 6 (T3) after surgery ended.
The results showed that the mean value of VAS-A
in 72 patients was 4.14 ± 1.9. The mean MAP in the
lidocaine group was 91.4 ± 6.8 mmHg while in the
placebo group was slightly higher, which was 92.2 ± 5.2
mmHg (p = 0.541). The mean heart rate in the lidocaine
group was 78.0 ± 6.06 times per minute while in the
placebo group was slightly higher, which was 84.4 ± 7.3
times per minute (p = 0.003). In the lidocaine group,
there was no correlation between MAP and
postoperative VAS values (r = -0.106; p = 0.324) and a
low negative correlation between heart rate and
postoperative VAS values (r = -0.201; p = 0.524). VAS
values in the lidocaine and placebo groups showed a
significant difference in T0 observations (p = 0.039).
VAS values in the lidocaine group were lower than
those in the placebo group at T0 observations, but not
significantly different in T1, T2, and T3 observations.
Keywords : Postoperative Pain, Lidocaine, Hemodynamics.