Effectiveness of Mifepristone – Misoprostol Combination in Medical Termination of Early Pregnancy


Authors : Surg Lt. Dr Devdatt l Pitale

Volume/Issue : Volume 2 - 2017, Issue 9 - September

Google Scholar : https://goo.gl/NoJ6iA

Scribd : https://goo.gl/5UfHTS

Thomson Reuters ResearcherID : https://goo.gl/3bkzwv

Introduction: Unplanned and unwanted pregnancies are common worldwide despite of the medical advancements and wider availability of contraceptive methods. It is thus highly desirable to have a safe and cost effective method of abortion.Aim: To study the effectiveness of Mifepristone 200 mg orally followed by Misoprostol 800 µg intravaginally 48 hours later in women undergoing medical termination of early pregnancy.Materials and methods: This study included 50 pregnant women with gestational age up to 63 days from the day one of the L.M.P ,without any contraindications to the regimen.Results: Majority of the pregnant women belonged to the age group between 26-30 years. 30% of these women were nulliparous and 70 % were multiparous. The period of gestation varied from 35-63 days.96% of the patients had complete abortion and 4% had incomplete abortion. All the patients expelled the products of conception within 24 hours of prostaglandin administration. The adverse effects reported were nausea reported by 20%, vomiting by 10% and diarrhea by 4% of the cases. None of the patients reported excess bleeding at the time of abortion, hospitalization or blood transfusion. This regimen has the effectiveness of complete abortion rate with few side effects.Conclusion: The Mifepristone- Misoprostol combination offers an effective, acceptable, out-patient procedure and an alternative to surgical methods of abortion in medical termination of early pregnancy (up to 63 days of gestation).

Keywords : Mifepristone, Misoprostol, Abortion.

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