Lateral epicondylitisis the most common overuse syndrome in the elbow, due to injury to the muscles originate on the lateral epicondylar region of the distal humerus. This study was done to assess the effectiveness of Mulligan’s Mobilization versus Eccentric Exercises in subjects with Lateral Epicondylitis. Methods: Lateral Epicondylitis (LE) subjects, diagnosed by Orthopedician were included according to the inclusion criteria and obtained in writing with their consent. Randomly, 60 subjects were split into two groups of 30 each. Group A received Mulligan’s Mobilization where Group B received Eccentric exercises and the treatment was given for 12 sessions in 4 weeks. After the treatment, subjects were evaluated for their pain profile using visual analogue scale, grip strength by Hand dynamometer and functional activity by PRTEE questionnaire. Results: Paired t-test analysis was used to compare groups within each, and independent t-test analysis was performed to compare groups between each. Both groups were similarly efficient in reducing pain after 4 weeks (p>0.05), however Group B had a statistically significant improvement in hand grip strength and functional activities. Conclusion: This study concludes that, both Mulligan’s Movement and Eccentric Exercise Techniques are equally effective in reducing pain, whereas Eccentric Exercise found to be very effective in improving Hand Grip Strength and functional activity. Keywords- Lateral Epicondylitis, Mulligan’s Mobilization, Eccentric Exercises, Visual Analogue Scale (VAS), Hand-held Dynamometer, Patient Rated Tennis Elbow Evaluation Questionnaire (PRTEE Questionnaire).