Authors :
Anyanebechi Chidimma Linda; Asomugha Azuoma Lasbery
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
DOI :
https://doi.org/10.5281/zenodo.7439841
Abstract :
Estrogen is the most commonly prescribed
drug as an oral contraceptives and hormonal replacement
therapy in women. The present study was conducted to
examine the possible effects of turmeric against
Mammary gland toxicity induced by estrogen in female
wistar rats. 35 female Wistar rats were assigned into five
(7) groups of five (5) rats each after a period of two (2)
weeks of acclimatization; the first group which was the
control group was the control group, Group 2 received
estrogen only, group 3 and group 4 received turmeric and
estrogen together, group 5 received turmeric only while
group 6 and 7 were pre-treated with turmeric before they
were given estrogen orally. At the end of experimental
period the animals were weighed and then sacrificed by
decapitation under diethyl ether anesthesia. The
mammary gland tissues were harvested for histological
examination. The histological examination showed that
the animals treated with estrogen alone induced ductal
epitheliosis while the Concurrent administration of
estrogen and turmeric as well as pre-treatment with
turmeric retained the normal ductal epithelial status.
Keywords :
Estrogen, Turmeric, Mammary Gland, Histology.
Estrogen is the most commonly prescribed
drug as an oral contraceptives and hormonal replacement
therapy in women. The present study was conducted to
examine the possible effects of turmeric against
Mammary gland toxicity induced by estrogen in female
wistar rats. 35 female Wistar rats were assigned into five
(7) groups of five (5) rats each after a period of two (2)
weeks of acclimatization; the first group which was the
control group was the control group, Group 2 received
estrogen only, group 3 and group 4 received turmeric and
estrogen together, group 5 received turmeric only while
group 6 and 7 were pre-treated with turmeric before they
were given estrogen orally. At the end of experimental
period the animals were weighed and then sacrificed by
decapitation under diethyl ether anesthesia. The
mammary gland tissues were harvested for histological
examination. The histological examination showed that
the animals treated with estrogen alone induced ductal
epitheliosis while the Concurrent administration of
estrogen and turmeric as well as pre-treatment with
turmeric retained the normal ductal epithelial status.
Keywords :
Estrogen, Turmeric, Mammary Gland, Histology.
