Authors : Dr. P. Bhavan Vedha; Dr. Naveen Angadi

Volume/Issue : Volume 10 - 2025, Issue 3 - March

---

Google Scholar : https://tinyurl.com/2kwurb23

Scribd : https://tinyurl.com/n8ut8s9n

DOI : https://doi.org/10.38124/ijisrt/25mar1877

Google Scholar

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 15 to 20 days to display the article.

---

Abstract : Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus, commonly associated with hyperglycemia, metabolic acidosis, and ketosis. While elevated serum amylase and lipase levels are traditionally linked to acute pancreatitis, recent studies suggest that they can be elevated in DKA patients without pancreatic involvement. This study aims to investigate the frequency and possible causes of elevated amylase and lipase levels in DKA patients and assess their correlation with metabolic parameters and clinical outcomes.

Keywords : Diabetic Ketoacidosis, Amylase, Lipase, Pancreatitis, Metabolic Derangements, Serum Enzymes, Insulin Deficiency.

References :

1. American Diabetes Association. “Diabetic ketoacidosis (DKA): Pathophysiology and treatment.” Diabetes Care, 2022.
2. Nair, S., Yadav, D., Pitchumoni, C.S. (2000). “Association of diabetic ketoacidosis and acute pancreatitis: Observations in 100 cases.” Pancreas, 30(2), 198-203.
3. Ajaydas, R., et al. (2013). “Serum amylase and lipase levels in diabetic ketoacidosis: Incidence and clinical significance.” Indian Journal of Endocrinology and Metabolism, 17(5), 803-806.
4. Chandra, P., et al. (2022). “Amylase and lipase elevation in diabetic ketoacidosis without acute pancreatitis.” Journal of Diabetes Research, 2022, 1-7.
5. Umpierrez, G.E., et al. (2002). “Diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome.” New England Journal of Medicine, 346(11), 794-800.
6. Banks, P.A., Freeman, M.L. (2006). “Practice guidelines in acute pancreatitis.” American Journal of Gastroenterology, 101(10), 2379-2400.