Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to tooth to promote ion deposition into crystal voids in demineralized enamel to produce net mineral gain. The remineralization produced by saliva is less and also a slow process, therefore remineralizing agents are required. Biomimetic approaches to stabilization of bio available calcium, phosphate, and fluorideions and the localization of these ions to noncavitated caries lesions for controlled remineralization shows great promise for the non-invasive management of dental caries. The aim of this article is to give a brief update about remineralization agent aiming to “treat early caries lesion" non-invasively

Keywords : Calcium-phosphate-based systems; Remineralization; fluoride; Non-invasive treatment.