Authors : Pradeepa Subramanian; Chithra Shanmugasundaram; Jesteena Johney; Ragunathan R; Sam Ebenezer Rajadas

Volume/Issue : Volume 8 - 2023, Issue 5 - May

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/2nrrj2fc

DOI : https://doi.org/10.5281/zenodo.8042674

Abstract : One of the main cancers that kill women globally is cervical cancer, which has limited infectiousness and behaves epidemiologically like a vaginal illness. In a concept of multifactorial, stepwise carcinogenesis at the cervix uteri, smoking, and human papillomavirus (HPV) 16/18 are currently significant problems. Hence there is a need for therapeutics with lesser or no side effects. Grapes (Vitis vinifera) have recently gained scientific attention. Its rich high polyphenol content has been shown to improve human health, particularly in the prevention of cancer and cardiovascular disease. Resveratrol, quercetin, catechin/epicatechin, and other polyphenol bioactive compounds are present in significant amounts in grapes. Preservation of these contents is challenging to achieve significant shelf-life. In this study, we employed microencapsulation techniques to design a carrier medium that could preserve the Using the agar diffusion method, the encapsulated aqueous grape seed extract’s antibacterial activity was assessed against Gram- negative bacteria, and anticancer activity was analyzed using Hela-cell lines.The outcome of the study, clearly indicates that the encapsulation does not alter the activity of the lead molecules present in the grape seed extract.

Keywords : Vitis Vinifera, Cervical cancer, Antioxidants, Polyphenol, Antibacterial and anti-cancer activity.