Authors : Manogna N.; Aravind K.; Lakshmi Talari

Volume/Issue : Volume 11 - 2026, Issue 3 - March

Google Scholar : https://tinyurl.com/4byx2s65

Scribd : https://tinyurl.com/345tp4zp

DOI : https://doi.org/10.38124/ijisrt/26mar347

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : This systematic review synthesizes evidence from 10 studies published between 2005 and 2025, focusing on nutritional interventions, functional ingredients, and their resulting health outcomes in dogs and cats. The scope of the review covers research into cognitive function enhancement, osteoarthritis management, palatability assessment, periodontal disease prevention, aging interventions, plant extracts, nutrigenomics, microbiome modulation, and metabolomics. The studies included systematic reviews (n=8) and primary research examining enriched diets, nutraceuticals, and functional ingredients across various health domains. The evidence demonstrates beneficial effects for omega-3 fatty acids in improving cognitive function and managing osteoarthritis, with effect sizes (Cohen's d) ranging from d=0.58 to d=1.19. However, significant methodological heterogeneity is apparent, characterized by median sample sizes of only 11.5 animals per group and widely varying intervention durations, from 28 days to 3 years.  Key Research Gaps Identified:  Insufficient long-term safety data for most interventions, compounded by limited regulatory oversight in the supplement market. [1]  Lack of standardized outcome measures and validated biomarkers, particularly in fields like osteoarthritis management, where there is no current consensus on the most useful endpoints. [2]  Limited species-specific research, particularly for cats, presenting a critical taxonomic bias.  Poor integration of physiological and behavioral measures, especially in palatability research.  Minimal translation of biological findings into practical clinical protocols. The review highlights opportunities for developing validated biomarkers, standardized protocols, and evidence-based clinical pathways while addressing existing geographic, taxonomic, and methodological biases in the current research landscape

References :

1. Allen, T. J., & Ramey, D. W. (2021). Veterinary pet supplements and nutraceuticals. Veterinary Clinics of North America: Small Animal Practice, 51(1), 173–189..
2. Barbeau-Grégoire, M., Otis, C., Cournoyer, A., Moreau, M., Lussier, B., & Troncy, É.19 (2022). A 2022 systematic review and meta-analysis of enriched therapeutic diets and nutraceuticals in canine and feline osteoarthritis.20 International Journal of Mole.
3. Blanchard, T., Eppe, J., Mugnier, A., Delfour, F., & Meynadier, A. (2025). Enhancing cognitive functions in aged dogs and cats: A systematic review of enriched diets and nutraceuticals.21 GeroScience..
4. Brown, D. C., Boston, R. C., Coyne, J. C., & Farrar, J. T. (2018). What can we learn from osteoarthritis pain in companion animals? Clinical and Experimental Rheumatology, 36(5 Suppl 114), 54–61..
5. Cook, J. L., Evans, R., Lascelles, B. D. X., Brown, D. C., & Allen, D. (2010). Systematic review of outcome measures reported in clinical canine osteoarthritis research. Veterinary Surgery, 39(8), 917–928..
6. Guo, X., Wang, Y., Zhu, Z., & Li, L. (2024). The role of plant extracts in enhancing nutrition and health for dogs and cats: Safety, benefits, and applications. Veterinary Sciences, 11(2), 295..
7. Klinmalai, P., Kamonpatana, P., Sodsai, J., Promhuad, K., Srisa, A., Laorenza, Y., Kovitvadhi, A., Areerat, S., Seubsai, A., & Harnkarnsujarit, N. (2025).22 Modern palatant strategies in dry and wet pet food: Formulation technologies, patent innovations,.
8. Logan, E. I., P. R. L., R. A., A. R., & Hale, F. A. (2005). Evidence-based veterinary dentistry: A systematic review of homecare for prevention of periodontal disease in dogs and cats.23 Journal of Veterinary Dentistry, 22(2), 101–105..
9. Vlachou, G., Anagnostou, T., Kouskouni, E., Georgiopoulos, K., & Tzoumas, V. (2022). Palatability assessment of oral dosage forms for companion animals: A systematic review. Journal of Drug Delivery Science and Technology, 76, 103738..
10. Wernimont, S., Radosevich, J. L., Jackson, M. I., Ephraim, E., Badri, D., MacLeay, J., Jewell, D., & Suchodolski, J. (2020). The effects of nutrition on the gastrointestinal microbiome of cats and dogs: Impact on health and disease. Frontiers in Microbiol.