Environmentally Benign Synthesis of 2-Substituted4,6-Diaryl Pyrimidines Using Inorganic Solid Supports and their Biological Screening


Authors : Lekhni Sharma; Prakash C. Choudhary

Volume/Issue : Volume 6 - 2021, Issue 8 - August

Google Scholar : http://bitly.ws/9nMw

Scribd : https://bit.ly/3Cf5ldk

- A series of 2-(4-morpholinyl/1-piperidinyl/1- pyrrolidinyl)-4,6-diaryl pyrimidines (4a-r) have been synthesized by the condensation of 1,3-diarylpropenones with dicyandiamide (DDA) in presence of heterocyclic secondary amines such as morpholine, piperidine and pyrrolidine under conventional and nonconventional method, using inorganic supports {Fly ash supported Ba(OH)2}. The synthesis highlights a comparative study of conventional, and ultrasonication technique. The reaction time decreases from hours to minutes along with yields enhancement under ultrasound irradiation. In addition, catalytic role of Fly ash supported Ba(OH)2 was studied with different catalytic load. All the products have been characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Some representative compounds were screened for their antibacterial assay and showed excellent activity.

Keywords : Pyrimidine, DDA, heterocyclic secondary amines, ultrasound irradiation, antibacterial screening.

CALL FOR PAPERS


Paper Submission Last Date
31 - March - 2024

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe