Authors :
Lekhni Sharma; Prakash C. Choudhary
Volume/Issue :
Volume 6 - 2021, Issue 8 - August
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3Cf5ldk
Abstract :
- A series of 2-(4-morpholinyl/1-piperidinyl/1-
pyrrolidinyl)-4,6-diaryl pyrimidines (4a-r) have been
synthesized by the condensation of 1,3-diarylpropenones
with dicyandiamide (DDA) in presence of heterocyclic
secondary amines such as morpholine, piperidine and
pyrrolidine under conventional and nonconventional
method, using inorganic supports {Fly ash supported
Ba(OH)2}. The synthesis highlights a comparative study
of conventional, and ultrasonication technique. The
reaction time decreases from hours to minutes along
with yields enhancement under ultrasound irradiation.
In addition, catalytic role of Fly ash supported Ba(OH)2
was studied with different catalytic load. All the
products have been characterized by IR, 1H NMR, 13C
NMR and mass spectral studies. Some representative
compounds were screened for their antibacterial assay
and showed excellent activity.
Keywords :
Pyrimidine, DDA, heterocyclic secondary amines, ultrasound irradiation, antibacterial screening.
- A series of 2-(4-morpholinyl/1-piperidinyl/1-
pyrrolidinyl)-4,6-diaryl pyrimidines (4a-r) have been
synthesized by the condensation of 1,3-diarylpropenones
with dicyandiamide (DDA) in presence of heterocyclic
secondary amines such as morpholine, piperidine and
pyrrolidine under conventional and nonconventional
method, using inorganic supports {Fly ash supported
Ba(OH)2}. The synthesis highlights a comparative study
of conventional, and ultrasonication technique. The
reaction time decreases from hours to minutes along
with yields enhancement under ultrasound irradiation.
In addition, catalytic role of Fly ash supported Ba(OH)2
was studied with different catalytic load. All the
products have been characterized by IR, 1H NMR, 13C
NMR and mass spectral studies. Some representative
compounds were screened for their antibacterial assay
and showed excellent activity.
Keywords :
Pyrimidine, DDA, heterocyclic secondary amines, ultrasound irradiation, antibacterial screening.
