Epstein Barr Virus's Role in Cancer and Its Association with the p53 Family in Inhibiting Apoptosis


Authors : Suparna Maji; Soumyadipta Das

Volume/Issue : Volume 6 - 2021, Issue 7 - July

Google Scholar : http://bitly.ws/9nMw

Scribd : https://bit.ly/3y6Hk6B

Epstein Barr Virus (EBV), belonging to the family of herpes virus, widely responsible for initiating a long-lasting infection that infects more than 90% of the adult human population world-wide. Apart from being a chronic B-Lymphocyte infecting virus with common symptoms associated with fever, sore throat, lymphadenopathy etc., the viral proteins have been reported to be linked to different types of human carcinomas & lymphomas in the long run. The approach of this review is mostly to bring forward the insights of some of the potent carcinomas that are directly related to the pathogenesis of this virus, elucidating the viral proteins -: EBNA-1, EBNA-2, EBNA-LP, EBNA-3A, 3B, 3C, LMP-1, their direct association with human p53, p63, p73 & their isoforms in regulating the tumour inducing pathways, along with this some of the recent therapeutic approaches in preventing the EBV linked carcinogenesis has also been incorporated in this review.

Keywords : Epstein Barr Virus (EBV), p53, p63, p73, EBNA, LMP, Lymphoma, Malignancy, CRISPR, CAR-T Cell

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