Authors : Dr. Junior Sundresh N.; Lakshminarayanan S.; Subanithi B.

Volume/Issue : Volume 10 - 2025, Issue 8 - August

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DOI : https://doi.org/10.38124/ijisrt/25aug711

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Abstract : Acute appendicitis (AA) remains one of the most common causes for emergency abdominal surgery worldwide, though recent evidence supports non-operative management of uncomplicated cases with intravenous (IV) antibiotics, particularly in resource-limited settings or during global health crises like COVID-19. This prospective observational study included 50 clinically and radiologically diagnosed patients with uncomplicated AA who were treated conservatively with IV antibiotics, either Ciprofloxacin + Metronidazole or Piperacillin + Tazobactam. Data on demographics, imaging (USG/CT), Alvarado score, comorbidities, clinical response, and outcomes were collected and analyzed. Results showed that 72% of patients were cured with antibiotics, 12% experienced partial relief, 6% showed no change, 4% worsened, and 6% eventually required surgery, with complications being minimal and mostly gastrointestinal. Statistical analysis revealed no significant correlation between specific antibiotic regimens and outcomes (p = 0.73), though higher Alvarado scores were positively associated with improved outcomes (p = 0.039). In conclusion, conservative management with IV antibiotics is a safe and effective alternative to surgery in carefully selected patients with uncomplicated AA, with clinical scoring and imaging playing a vital role in patient selection and monitoring.

Keywords : Acute Appendicitis, IV Antibiotics, Conservative Treatment, Alvarado Score, Non-Operative Management.

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