Chronic Obstructive Pulmonary Disease (COPD) is one of public health problem in Indonesia, which is caused by smoking and air pollution. Treatment with antibiotics prevent COPD exacerbations and improve patient quality of life. Inappropriate use of antibiotics lead to ineffective treatment, decrease patient safety, increase of resistance and treatment cost. This study aims to evaluate the appropriateness use of antibiotics in COPD patients. This is a descriptive retrospective study based on Gyssens method that using patient medical records during the period January- December 2015 in Outpatients Installation of Lung Hospital, West Sumatera.The number of patients who fulfill the inclusion criteria are 86 patients.

Keywords : Evaluation of antibiotic; gyssen method; COPD; rationality.