Authors : Abhijit V. Nikam; Ramprasad P. Mandade; Govind V. More

Volume/Issue : Volume 8 - 2023, Issue 12 - December

Google Scholar : http://tinyurl.com/5aa24kvx

Scribd : http://tinyurl.com/2s3wmpz4

DOI : https://doi.org/10.5281/zenodo.10421755

Abstract : The present study was planned to investigate possible antipyretic activity of ethanolic and methanolic extracts of leaves of the plant Clerodendruminfortunatum in Wistar rats. The plant leaves were collected, dried, powdered and defatted with petroleum ether and then subsequently subjected for 50% ethanolic and 50% methanolic extracts in Soxhlet’s apparatus. Total 30 Wistar rats of either sex weighing 250 to 300 gm were used for the study. The pyrexia was induced with subcutaneous injection of 20% Brewer’s yeast in the neck region. A stable pyrexia was achieved 18 hrs post injection. The rats were divided into 5 groups comprising 6 rats each. The group T1 and T2 were normal and pyretic control respectively, treated with 1ml of normal saline orally. The group T3 was treated with standard antipyretic drug, paracetamol at the rate of 10mg/kg body weight orally. Groups T4 and T5 were treated with 50% ethanolic and 50% methanolic extracts respectively at the rate of 400mg/kg body weight orally. The body temperature was recorded at an interval of 30 min, 60min, 180min an 360min post treatment. Both the extracts significantly restored the elevated body temperature at all the time interval and the result obtained was comparable with standard drug paracetamol. The findings of the study indicate that the plant Clerodendruminfortunatum possesses antipyretic activity and further investigations are necessary to confirm the activity.

Keywords : Clerodendruminfortunatum, Brewer’s yeast,methanolic extract.