Evaluation of Hepatocurative Effect of Aqueous Extract of Calotropis Procera (Tunfafiya) Leave on Acetaminophen Induced Albino Rat


Authors : UTHMAN K. S, RHAPHEL O.

Volume/Issue : Volume 5 - 2020, Issue 3 - March

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/39B7OAf

The hepatocurative effect of aqueous extract of calotropis procera (tunfafiya) leave on acetaminophen induced albino rat was investigated. Twenty four (24) albino rats were grouped into four groups, six rats (6) per group, group 1(positive control) was the normal and group 2 was the negative control which was induced but not treated. Group 3 and 4 were induced and treated with 200mg/kg and 400mg/kg respectively. Six parameters were tested which include aspartate transaminase(AST), alanine transaminase(ALT), total bilirubin(TB), direct bilirubin(DB), Albumin(ALB) and Total protein(TP). The mean value obtained in group 3 and 4 were significantly high (p<0.05) for AST, ALT and Bilirubin, however, the mean value for Albumin and Total protein were lower (p<0.05) as compared with the control, but there was significant reduction in the mean value of AST, ALT and Bilirubin when treated with the aqueous extract of calotropis procera with remarkable increase in the Albumin and Total protein, when compared with the negative control. This signifies the heptocurative properties of C. procera.

Keywords : Calotropis procera, Acetaminophen.

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