The hepatocurative effect of aqueous extract
of calotropis procera (tunfafiya) leave on
acetaminophen induced albino rat was investigated.
Twenty four (24) albino rats were grouped into four
groups, six rats (6) per group, group 1(positive control)
was the normal and group 2 was the negative control
which was induced but not treated. Group 3 and 4 were
induced and treated with 200mg/kg and 400mg/kg
respectively. Six parameters were tested which include
aspartate transaminase(AST), alanine
transaminase(ALT), total bilirubin(TB), direct
bilirubin(DB), Albumin(ALB) and Total protein(TP).
The mean value obtained in group 3 and 4 were
significantly high (p<0.05) for AST, ALT and Bilirubin,
however, the mean value for Albumin and Total protein
were lower (p<0.05) as compared with the control, but
there was significant reduction in the mean value of
AST, ALT and Bilirubin when treated with the aqueous
extract of calotropis procera with remarkable increase
in the Albumin and Total protein, when compared with
the negative control. This signifies the heptocurative
properties of C. procera.
Keywords : Calotropis procera, Acetaminophen.