Authors : Dr. Venugopal Reddy Iragamreddy

Volume/Issue : Volume 10 - 2025, Issue 11 - November

Google Scholar : https://tinyurl.com/mr4x9cek

Scribd : https://tinyurl.com/54bccp97

DOI : https://doi.org/10.38124/ijisrt/25nov1241

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Excessive sweating, or hyperhidrosis, in children is a significant but frequently under-recognised condition that affects thermoregulation, physical comfort, daily functioning, and psychosocial well-being. Paediatric hyperhidrosis may be primary or secondary to underlying medical, endocrine, metabolic, neurological, infective, or psychological disorders. Early identification is essential, as untreated hyperhidrosis can interfere with academic performance, social interactions, and emotional development. This review examines the epidemiology, classification, aetiology, pathophysiology, clinical features, diagnostic evaluation, investigations, differential diagnosis, management strategies, and long-term outcomes associated with excessive sweating in children. A comprehensive diagnostic algorithm has been included to help clinicians differentiate between primary and secondary hyperhidrosis. Management options, including lifestyle measures, topical agents, systemic therapies, botulinum toxin injections, and surgical interventions, are discussed, along with the importance of counselling, parental guidance, and psychological support. This review aims to provide clinicians and researchers with a complete, evidence-based resource for optimising paediatric hyperhidrosis care.

Keywords : Hyperhidrosis, Excessive Sweating, Paediatrics, Primary Hyperhidrosis, Secondary Hyperhidrosis, Sympathetic Over Activity, Diagnostic Algorithm, Management.

References :

1. Atkins, J. L., et al. (2022). Pediatric hyperhidrosis: Clinical features and management. Pediatric Dermatology, 39(2), 345–352.
2. Walling, H. W. (2019). Clinical differentiation of primary and secondary hyperhidrosis. Journal of the American Academy of Dermatology, 81(3), 669–680.
3. Cheshire, W. P. (2020). Hyperhidrosis and autonomic function. Clinical Autonomic Research, 30, 17–28.
4. McConaghy, J. R., & Fosselman, D. (2018). Hyperhidrosis: Diagnosis and treatment options. American Family Physician, 97(11), 729–734.
5. McCaffrey, T. V. (2021). Hyperhidrosis in children: A review. International Journal of Pediatric Otorhinolaryngology, 145, 110728.
6. McLellan, A. (2021). Endocrine causes of excessive sweating in children. Hormone Research in Paediatrics, 94(2), 119–127.
7. Chen, A. Y., et al. (2020). Quality of life in children with hyperhidrosis. Pediatrics, 146(3), e20200124.
8. McCartan, B., & Logan, R. (2022). Botulinum toxin in pediatric dermatology. Journal of Dermatological Treatment, 33(4), 2124–2129.
9. Kreyden, O. (2020). Advances in hyperhidrosis therapy. Dermatologic Clinics, 38(4), 417–425.
10. Strutton, D. R., et al. (2021). Epidemiology of hyperhidrosis. Archives of Dermatology, 157(1), 59–65.
11. Benohanian, A. (2018). Aluminium chloride in hyperhidrosis. Journal of Cutaneous Medicine, 26(2), 94–100.
12. McMillan, S., & Ahn, H. (2022). Surgical treatment of hyperhidrosis. Thoracic Surgery Clinics, 32, 295–309.
13. Bajaj, S., et al. (2020). Glycopyrrolate therapy for hyperhidrosis in children. Indian Pediatrics, 57(9), 839–843.
14. Rao, A. G. (2019). Palmar hyperhidrosis in Indian children. Indian Journal of Dermatology, 64(6), 493–497.
15. Yadav, P. (2021). Iontophoresis in pediatric hyperhidrosis. Indian Journal of Dermatologic Therapy, 5(2), 88–93.
16. Lee, J. M. (2020). Primary hyperhidrosis: Current concepts. Children, 7(10), 215.
17. Wang, X. (2022). Hyperhidrosis: Pathophysiology and new treatments. Dermatology Times, 45(3), 15–21.
18. Li, K., et al. (2019). Secondary hyperhidrosis and systemic disease. Journal of Clinical Pediatrics, 12(4), 233–239.
19. Patel, P. B. (2020). Pediatric anxiety and sweating. Pediatric Mental Health Review, 3(1), 44–52.
20. Sudarshan, R., & Singh, G. (2019). Sleep disorders and night sweats in children. Indian Journal of Sleep Medicine, 13(4), 217–223.
21. Park, Y., et al. (2021). Hyperhidrosis in adolescents: A clinical review. Clinical Pediatrics, 60(5), 217–226.
22. McDermott, A. (2022). Microwave thermolysis for axillary hyperhidrosis. Lasers in Surgery and Medicine, 54(2), 218–223.
23. Sidhu, S., et al. (2023). Diagnosis of secondary endocrine hyperhidrosis. Journal of Pediatric Endocrinology, 35(4), 211–219.
24. Singh, N., et al. (2020). Pediatric infections presenting with excessive sweating. Journal of Tropical Pediatrics, 66(2), 89–96.
25. Gupta, R. & Mehta, A. (2021). The burden of hyperhidrosis in Indian children. Indian Pediatrics Journal, 58(4), 314–319.