Authors :
Yuktha.S.Shreenivasan, Praveena. A.
Volume/Issue :
Volume 4 - 2019, Issue 6 - June
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/2X4oIRn
Abstract :
Nipah virus belongs to the family of Paramyxoviridae. It is a deadly virus which needs to be treated using a drug of increased efficacy and reduced toxicity. The main objective of this research is to identify the suitable drug molecule which could inhibit the escalation of this infection within the biological system susceptible to the infection. For this, bioinformatics tools were being exploited over the due course. Through literature survey, it was identified that the Nipah virus invades the susceptible human cell by adhering to the Ephrine B2 receptor through the viral phosphoprotein and glycoprotein moieties respectively. The novel approach of blocking the Ephrine B2 receptor using an organic compound is proposed in this paper to be effective in preventing the emerging Nipah virus. Further the docking studies of alkaloid Berberine with the Ephrine B2 receptor B and D chains in particular gave the docking energy as -5.65 kcal/mol which reveals a significant interaction between the target protein and the ligand molecule. The ligand further obeys Lipinski’s rule of 5, which provides Berberine therapeutic advantages in treatment of this deadly disease.
Keywords :
Berberine, Increased Efficacy, Molecular Docking, Lipinski’s Rule.
Nipah virus belongs to the family of Paramyxoviridae. It is a deadly virus which needs to be treated using a drug of increased efficacy and reduced toxicity. The main objective of this research is to identify the suitable drug molecule which could inhibit the escalation of this infection within the biological system susceptible to the infection. For this, bioinformatics tools were being exploited over the due course. Through literature survey, it was identified that the Nipah virus invades the susceptible human cell by adhering to the Ephrine B2 receptor through the viral phosphoprotein and glycoprotein moieties respectively. The novel approach of blocking the Ephrine B2 receptor using an organic compound is proposed in this paper to be effective in preventing the emerging Nipah virus. Further the docking studies of alkaloid Berberine with the Ephrine B2 receptor B and D chains in particular gave the docking energy as -5.65 kcal/mol which reveals a significant interaction between the target protein and the ligand molecule. The ligand further obeys Lipinski’s rule of 5, which provides Berberine therapeutic advantages in treatment of this deadly disease.
Keywords :
Berberine, Increased Efficacy, Molecular Docking, Lipinski’s Rule.
