Exploring the Horizons of Ephrin B2 Receptor for Combating Paramoxyviridae Infection


Authors : Yuktha.S.Shreenivasan, Praveena. A.

Volume/Issue : Volume 4 - 2019, Issue 6 - June

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/2X4oIRn

Nipah virus belongs to the family of Paramyxoviridae. It is a deadly virus which needs to be treated using a drug of increased efficacy and reduced toxicity. The main objective of this research is to identify the suitable drug molecule which could inhibit the escalation of this infection within the biological system susceptible to the infection. For this, bioinformatics tools were being exploited over the due course. Through literature survey, it was identified that the Nipah virus invades the susceptible human cell by adhering to the Ephrine B2 receptor through the viral phosphoprotein and glycoprotein moieties respectively. The novel approach of blocking the Ephrine B2 receptor using an organic compound is proposed in this paper to be effective in preventing the emerging Nipah virus. Further the docking studies of alkaloid Berberine with the Ephrine B2 receptor B and D chains in particular gave the docking energy as -5.65 kcal/mol which reveals a significant interaction between the target protein and the ligand molecule. The ligand further obeys Lipinski’s rule of 5, which provides Berberine therapeutic advantages in treatment of this deadly disease.

Keywords : Berberine, Increased Efficacy, Molecular Docking, Lipinski’s Rule.

CALL FOR PAPERS


Paper Submission Last Date
31 - March - 2024

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe