Authors : Dr. Dinesh Raja; Dr. Akhilesh Chandra; Dr. Tumpuri Srilatha; Dr. Trupti Jain; Dr. Vineet Chauhan; Dr. Rahul Agrawal

Volume/Issue : Volume 8 - 2023, Issue 5 - May

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/mttwu2kh

DOI : https://doi.org/10.5281/zenodo.8115990

Abstract : Background: The objective of the study was to investigate the immune-histochemical expression of two proteins, galectin-1 and Np-63, in oral malignancy and lesions with and without epithelial dysplasia. The study aimed to compare the expression of these proteins in normal oral epithelium, oral squamous cell carcinoma (OSCC), potentially malignant oral disorders (PMODs) with and without epithelial dysplasia. Methods: Immuno-histochemical staining for galectins-1 and Np-63 was evaluated in 25 samples of normal oral epithelium, 25 samples of oral squamous cell carcinoma, 25 samples of PMODS with dysplasia and 25 samples of PMODs without dysplasia. Analyzed the data using the Chi-Square test. The result were presented descriptive statistics (frequency and percentage), it was adopted the value of P <0.05 for statistical significance. Results: No significant difference was found in the inter group comparison of Gal-1 and Np-63 expression, indicating no abrupt change in expression of these markers in epithelium of normal mucosa, PMODs with and without dysplasia and OSCCs. Conclusion: Regarding the prognosis of different PMODs with and without dysplasia and different grades of OSCCs, no significant difference was found in the expression of both IHC markers. Therefore, the role of these markers as predicting/prognostic markers is questionable.

Keywords : OSCC, Epithelial Dysplasia, PMODS, IHC, Immuno-staining, Gal-1& Np-63.