Authors :
Dr. Dinesh Raja; Dr. Akhilesh Chandra; Dr. Tumpuri Srilatha; Dr. Trupti Jain; Dr. Vineet Chauhan; Dr. Rahul Agrawal
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/mttwu2kh
DOI :
https://doi.org/10.5281/zenodo.8115990
Abstract :
Background: The objective of the study was to investigate
the immune-histochemical expression of two proteins,
galectin-1 and Np-63, in oral malignancy and lesions with
and without epithelial dysplasia. The study aimed to
compare the expression of these proteins in normal oral
epithelium, oral squamous cell carcinoma (OSCC),
potentially malignant oral disorders (PMODs) with and
without epithelial dysplasia.
Methods: Immuno-histochemical staining for galectins-1
and Np-63 was evaluated in 25 samples of normal oral
epithelium, 25 samples of oral squamous cell carcinoma,
25 samples of PMODS with dysplasia and 25 samples of
PMODs without dysplasia. Analyzed the data using the
Chi-Square test. The result were presented descriptive
statistics (frequency and percentage), it was adopted the
value of P <0.05 for statistical significance.
Results: No significant difference was found in the inter
group comparison of Gal-1 and Np-63 expression,
indicating no abrupt change in expression of these
markers in epithelium of normal mucosa, PMODs with
and without dysplasia and OSCCs.
Conclusion: Regarding the prognosis of different PMODs
with and without dysplasia and different grades of
OSCCs, no significant difference was found in the
expression of both IHC markers. Therefore, the role of
these markers as predicting/prognostic markers is
questionable.
Keywords :
OSCC, Epithelial Dysplasia, PMODS, IHC, Immuno-staining, Gal-1& Np-63.
Background: The objective of the study was to investigate
the immune-histochemical expression of two proteins,
galectin-1 and Np-63, in oral malignancy and lesions with
and without epithelial dysplasia. The study aimed to
compare the expression of these proteins in normal oral
epithelium, oral squamous cell carcinoma (OSCC),
potentially malignant oral disorders (PMODs) with and
without epithelial dysplasia.
Methods: Immuno-histochemical staining for galectins-1
and Np-63 was evaluated in 25 samples of normal oral
epithelium, 25 samples of oral squamous cell carcinoma,
25 samples of PMODS with dysplasia and 25 samples of
PMODs without dysplasia. Analyzed the data using the
Chi-Square test. The result were presented descriptive
statistics (frequency and percentage), it was adopted the
value of P <0.05 for statistical significance.
Results: No significant difference was found in the inter
group comparison of Gal-1 and Np-63 expression,
indicating no abrupt change in expression of these
markers in epithelium of normal mucosa, PMODs with
and without dysplasia and OSCCs.
Conclusion: Regarding the prognosis of different PMODs
with and without dysplasia and different grades of
OSCCs, no significant difference was found in the
expression of both IHC markers. Therefore, the role of
these markers as predicting/prognostic markers is
questionable.
Keywords :
OSCC, Epithelial Dysplasia, PMODS, IHC, Immuno-staining, Gal-1& Np-63.
