Extended Spectrum Beta-Lactamase (ESBL) Producing Multi Drug Resistant Gram-Negative Isolates Causing Urinary Tract Infection in a Tertiary Care Hospital


Authors : Santoshi Chaudhary; Aagya Dhital; Bidya Shrestha

Volume/Issue : Volume 6 - 2021, Issue 2 - February

Google Scholar : http://bitly.ws/9nMw

Scribd : https://bit.ly/30uk3MN

Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. MDR is the growing concern nowadays which is increasing significantly because of the unwanted use of antibiotics, bacteria to be more resistance producing ESBL in the near future. The aim of this study is to detect ESBL production in MDR Gramnegative bacteria causing UTIs. Among total samples received, 100 (22.0%) were reported to be gram negative bacilli. E. coli (n=75) was the dominant isolate. Out of total gram negative bacilli, 52 (52.0%) were found to be MDR. Highest rate of susceptibility of Gram negative bacteria was seen towards Piperacillin/Tazobactam (84.7%) and Amikacin (80.8%) and highly resistant to Amoxicillin (90.3%) followed by Cefixime (82.7%) and Imipenem (80.8%) in case of enterobacteriaceae. In addition, Acinetobacter spp. highly resistant (100%) to all the antibiotics used except for the Polymixin B and Tigecycline 100% susceptible. This study demonstrates the high prevalence of ESBL producers among E. coli followed by Citrobacter spp. Hence, controlling antibiotic resistant bacteria and subsequent infections more efficiently necessities the sensible and responsible use of antibiotics

Keywords : Urinary Tract Infection, MDR, ESBL.

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