Authors :
Dimba Marmo; Eveline Mboh Khan; Atanga D. Funwie; Foyeth Eugene
Volume/Issue :
Volume 11 - 2026, Issue 1 - January
Google Scholar :
https://tinyurl.com/34beuh8x
Scribd :
https://tinyurl.com/yxduad6v
DOI :
https://doi.org/10.38124/ijisrt/26jan1071
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Immunization is one of the most effective public health interventions, yet coverage remains critically low in fragile
districts of Cameroon’s Far North region. Insecurity, displacement, and sociocultural barriers contribute to persistent gaps,
leaving many children vulnerable to vaccine preventable diseases.
Objective:
To assess the prevalence and determinants of zero-dose and under-immunization among children aged 12–35 months
in fragile districts of the Far North region of Cameroon.
Methods:
A quantitative descriptive cross-sectional study was conducted between December 2024 and August 2025. Using
multistage random sampling, 383 mothers/guardians of eligible children were interviewed across 25 missed communities.
Data were collected through a structured, pre tested questionnaire and analyzed using descriptive statistics and logistic
regression. Dependent variables were zero dose (no DTP1) and under immunization (missed DTP3 or other vaccines).
Results:
Only 27% of respondents presented a vaccination card, and just 21% of children were fully vaccinated against EPI
diseases. The burden of missed immunization was extremely high: 51% of children were zero dose and 35% under
immunized, meaning 87% were either zero dose or under immunized. Although 48% had received RR doses, this partial
progress was insufficient to close the coverage gap. Females were disproportionately affected, with 29% never receiving
DTP1 compared to 19% of males. Logistic regression identified several significant determinants: maternal education (AOR
= 2.45, 95% CI: 1.30–4.62, p = 0.005), maternal autonomy (AOR = 0.62, 95% CI: 0.40–0.95, p = 0.03), household wealth
(AOR = 1.85, 95% CI: 1.10–3.12, p = 0.02), geographic barriers such as conflict affected or remote areas (AOR = 3.10, 95%
CI: 1.75–5.50, p < 0.001), and supply side constraints including vaccine stock outs (AOR = 2.20, 95% CI: 1.25–3.90, p =
0.006) and lack of trained staff (AOR = 1.70, 95% CI: 1.05–2.75, p = 0.03). Cultural attitudes such as refusal of male
vaccinators, lack of trust in health personnel, and religious restrictions were also independently associated with under
immunization (p < 0.05).
Conclusion:
Zero-dose and under-immunization remain alarmingly prevalent in fragile districts of Cameroon, with 87% of children
affected. Inferential analysis confirms that maternal education, autonomy, household wealth, geographic insecurity, and
health system constraints are statistically significant determinants. Addressing these barriers through targeted,
context-specific interventions is urgently needed to strengthen immunization coverage in fragile settings.
Keywords :
Zero-Dose, Unimmunized, Poor Immunization Coverage, Children, Missed Communities, Fragile Health Districts.
References :
- Afari-Asiedu, S., Febir, L. G., Tawiah, C., Omoleke, S., Ofosu-Apea, P., Osei-Sarpong, F., Ziao, A. M. C., Kyei, C., Apraku, E. A., Antwi, A., Kubio, C., Ofosu, A. A., Kwarteng, P. G., Shetye, M., & Asante, K. P. (2024). Factors influencing vaccination up-take among nomadic population in four regions of Ghana: A qualitative study. BMC Public Health, 24(1), 2921. https://doi.org/10.1186/s12889-024-20397-w
- Amoah, A., Issaka, J., Ayebeng, C., & Okyere, J. (2023). Influence of women empowerment on childhood (12–23 months) immunization coverage: Recent evidence from 17 sub-Saharan African countries. Tropical Medicine and Health, 51, 63. https://doi.org/10.1186/s41182-023-00556-2
- Bogale, B., Scambler, S., Mohd Khairuddin, A. N., & Gallagher, J. E. (2024). Health system strengthening in fragile and conflict-affected states: A review of systematic reviews. PLOS ONE, 19(6), e0305234. https://doi.org/10.1371/journal.pone.0305234
- Bowen, D. H., Casciola, L., Aimade, W., Lindeburg, E., Muhula, S. O., Osur, J., Rakhshani, N. S., Fayomi, S. A., Johnson, T., Holme, M., Vangsgaard, C., & ReD Trust Group. (2025). The Vaccine Trust Framework: Mixed-method development of a tool for understanding and quantifying trust in health systems and vaccines. The Lancet. Global Health, 13(9), e1553–e1563. https://doi.org/10.1016/S2214-109X(25)00245-1
- Cameroon. (n.d.). Retrieved December 23, 2025, from https://www.prc.cm/en/cameroon
- Epee, E., Tagne, C. F., Bakhtiari, A., Boyd, S., Willis, R., Harte, A. J., Jimenez, C., Burgert-Brucker, C., Goldman, W., Kello, A. B., Palmer, S., Houck, P., Reid, S., Toubali, E., Zhang, Y., Cohn, D. A., Gueye, F., Ngondi, J. M., Teta, I., … Bella, A. (2024). Assessing the prevalence of trachoma in the East, North, Far North and Adamaoua regions of Cameroon, 2016–2022. International Health, 17(3), 351–365. https://doi.org/10.1093/inthealth/ihae071
- Gisèle, E., Wafeu, G. S., Fai, K. N., Ewane, C., & Gisèle, E. (2025). Determinants of Use of Health Care Services and Immunization Uptake Among nomadic Populations of Northern Cameroon in a Humanitarian Context (No. 2025062047). Preprints. https://doi.org/10.20944/preprints202506.2047.v1
- Headley, T. Y., Shay, C. W., & Tozan, Y. (2025). The impact of armed conflict on vaccination coverage: A systematic review of empirical evidence from 1985 to 2025. Conflict and Health, 19(1), 71. https://doi.org/10.1186/s13031-025-00708-7
- Masemola, N. M., Burnett, R. J., Makamba-Mutevedzi, P. C., Schönfeldt, M., Bamford, L. J., Ismail, Z., Madhi, S. A., & Meyer, J. C. (2025). Vaccine stock-outs: A preventable health facility obstacle contributing to missed vaccinations in South African children. Vaccine, 45, 126583. https://doi.org/10.1016/j.vaccine.2024.126583
- Musa, M., & Abdullahi, A. (2025). Resilience Or Coping: Adaptive Livelihood Strategies and Their Nutritional Trade-Offs Among Conflict-Affected Pastoralist Communities in Katsina State, Nigeria. Journal of Current Research and Studies, 2(4), 120–138. https://doi.org/10.64321/jcr.v2i4.50
- Powell, M. P., Mufwambi, W., Hasan, A. Z., Dombola, A. M., Prosperi, C., Sakala, R., Kapungu, K., Chongwe, G., Singh, P., Wang, Q., Chewe, S., Mwansa, F. D., Sakala, C., Kamiji, E., Bobo, P., Matanda, K., Manda, J., Winter, A. K., Sauer, M., … Mutembo, S. (2025). School Entry Vaccination Checks Allow Mapping of Under-Vaccinated Children in Zambia. Vaccines, 13(9), 924. https://doi.org/10.3390/vaccines13090924
- Santos, T. M., Cata-Preta, B. O., Wendt, A., Arroyave, L., Blumenberg, C., Mengistu, T., Hogan, D. R., Victora, C. G., & Barros, A. J. D. (2024). Exploring the “Urban Advantage” in Access to Immunization Services: A Comparison of Zero-Dose Prevalence Between Rural, and Poor and Non-poor Urban Households Across 97 Low- and Middle-Income Countries. Journal of Urban Health: Bulletin of the New York Academy of Medicine, 101(3), 638–647. https://doi.org/10.1007/s11524-024-00859-7
- Summan, A., Nandi, A., Schueller, E., & Laxminarayan, R. (2022). Public health facility quality and child immunization outcomes in rural India: A decomposition analysis. Vaccine, 40(16), 2388–2398. https://doi.org/10.1016/j.vaccine.2022.03.017
- Tchuenga, G. T. S., Tchindjang, M., Ngome, P. I. T., Degrande, A., Basga, S. D., Saha, F., Tchuenga, G. T. S., Tchindjang, M., Ngome, P. I. T., Degrande, A., Basga, S. D., & Saha, F. (2024). Agricultural Innovations and Adaptations to Climate Change in the Northern Cameroon Region. Sustainability, 16(22). https://doi.org/10.3390/su162210096
- Vaccher, S., Laman, M., Danchin, M., Angrisano, F., & Morgan, C. (2025). Missed Measles Immunisations Places Individuals and Communities at Risk: The Equity Argument for Including Measles in Under-Immunised Definitions. Vaccines, 13(2), 108. https://doi.org/10.3390/vaccines13020108
- van Heemskerken, P. G., Decouttere, C. J., Broekhuizen, H., & Vandaele, N. J. (2022). Understanding the complexity of demand-side determinants on vaccine uptake in sub-Saharan Africa. Health Policy and Planning, 37(2), 281–291. https://doi.org/10.1093/heapol/czab139
- Wariri, O., & Utazi, C. E. (2025). Geospatial modelling of vaccination coverage in Africa: Addressing gaps, advancing equality, and realising promise. The Lancet. Global Health, 13(11), e1784–e1785. https://doi.org/10.1016/S2214-109X(25)00355-9
- Wiysonge, C. S., Uthman, M. M. B., Ndwandwe, D., & Uthman, O. A. (2025). Multilevel Analysis of Zero-Dose Children in Sub-Saharan Africa: A Three Delays Model Study. Vaccines, 13(9), 987. https://doi.org/10.3390/vaccines13090987
- Yakum, M. N., Atanga, F. D., Ajong, A. B., Eba Ze, L. E., & Shah, Z. (2023). Factors associated with full vaccination and zero vaccine dose in children aged 12-59 months in 6 health districts of Cameroon. BMC Public Health, 23(1), 1693. https://doi.org/10.1186/s12889-023-16609-4
Background:
Immunization is one of the most effective public health interventions, yet coverage remains critically low in fragile
districts of Cameroon’s Far North region. Insecurity, displacement, and sociocultural barriers contribute to persistent gaps,
leaving many children vulnerable to vaccine preventable diseases.
Objective:
To assess the prevalence and determinants of zero-dose and under-immunization among children aged 12–35 months
in fragile districts of the Far North region of Cameroon.
Methods:
A quantitative descriptive cross-sectional study was conducted between December 2024 and August 2025. Using
multistage random sampling, 383 mothers/guardians of eligible children were interviewed across 25 missed communities.
Data were collected through a structured, pre tested questionnaire and analyzed using descriptive statistics and logistic
regression. Dependent variables were zero dose (no DTP1) and under immunization (missed DTP3 or other vaccines).
Results:
Only 27% of respondents presented a vaccination card, and just 21% of children were fully vaccinated against EPI
diseases. The burden of missed immunization was extremely high: 51% of children were zero dose and 35% under
immunized, meaning 87% were either zero dose or under immunized. Although 48% had received RR doses, this partial
progress was insufficient to close the coverage gap. Females were disproportionately affected, with 29% never receiving
DTP1 compared to 19% of males. Logistic regression identified several significant determinants: maternal education (AOR
= 2.45, 95% CI: 1.30–4.62, p = 0.005), maternal autonomy (AOR = 0.62, 95% CI: 0.40–0.95, p = 0.03), household wealth
(AOR = 1.85, 95% CI: 1.10–3.12, p = 0.02), geographic barriers such as conflict affected or remote areas (AOR = 3.10, 95%
CI: 1.75–5.50, p < 0.001), and supply side constraints including vaccine stock outs (AOR = 2.20, 95% CI: 1.25–3.90, p =
0.006) and lack of trained staff (AOR = 1.70, 95% CI: 1.05–2.75, p = 0.03). Cultural attitudes such as refusal of male
vaccinators, lack of trust in health personnel, and religious restrictions were also independently associated with under
immunization (p < 0.05).
Conclusion:
Zero-dose and under-immunization remain alarmingly prevalent in fragile districts of Cameroon, with 87% of children
affected. Inferential analysis confirms that maternal education, autonomy, household wealth, geographic insecurity, and
health system constraints are statistically significant determinants. Addressing these barriers through targeted,
context-specific interventions is urgently needed to strengthen immunization coverage in fragile settings.
Keywords :
Zero-Dose, Unimmunized, Poor Immunization Coverage, Children, Missed Communities, Fragile Health Districts.