The key objective of this research was to establish the factors determining innovation outcomes in the chemist enterprises in Wote Municipality of Makueni County in Kenya. The constructs for the independent variable included knowledge management, strategic leadership, business model, and strategy, whereas that of the dependent variable were incremental, radical, breakthrough, and disruptive.  Design/Methodology/Approach: The target population was 70 chemist enterprises of which 40 of them formed the sample. Data was successfully collected using questionnaire, interviews, and observation from 35 respondent chemist enterprises representing 88% response rate. Data processing and analysis was done through application of the Statistical Package for Social Sciences (SPSS).  Findings: Test results show strategic leadership as the leading predictor of innovation outcomes with adjusted R 2 =0.713. The other independent variables, knowledge management, business model, and strategy with adjusted R 2 of 0.685, 0.594, and 0.296 followed respectively in descending order indicating lower prediction rates. Both the Kolmogorov-Smirnov test and Shapiro-Wilks test for normality revealed probabilities of more than 0.05 meaning that the data sets were normally distributed and all the four hypotheses were confirmed and accepted.  Originality/value: Some studies having dwelt on some analysis with findings of linkages in determining factors relating to innovation. The research undertaken here investigates individual and combined influence of the specific factors on innovation outcomes of an enterprise, as well as the prediction rate of the constructs, having not been revealed much in the available documented sources especially with reference to the retail business industry of the Kenyan economy. It is of great value addition in enhancing understanding of the contributing factors to higher levels of innovation outcomes in enterprises

Keywords : Innovation, Knowledge Management, Strategic Leadership, Business Model, Strategy, Radical Innovation, Incremental Innovation, Disruptive Innovation