Authors :
Pradnya Patil; Vaishali Rakibe; Tejal P. Patil; Dr. Rajanikant. T. Kakde; Jadhav M. M.
Volume/Issue :
Volume 9 - 2024, Issue 1 - January
Google Scholar :
http://tinyurl.com/bde8aed9
Scribd :
http://tinyurl.com/2v9dfum5
DOI :
https://doi.org/10.5281/zenodo.10518454
Abstract :
A sensitive first order derivative method has
been developed and validated for the determination of
Loperamide hydrochloridein formulations using
Methanol: HCL as a solvent. The drug showed
maximum absorbance at 259 nm and amplitude
measured in the range of 257 nm-275 nm. The drug
obeyed linearity in the range of 400-1400 μg/mL. The
present method was validated as per International
Conference on Harmonization guidelines. Percent
recovery for Loperamide hydrochloride was obtained in
the range of 97.90 - 99.99 % , indicates accuracy and %
RSD < 2, indicates precision of the method. The results
showed that the proposed method is suitable, precise,
accurate and rapid for determination of Loperamide
hydrochloride in bulk, its tablet dosage forms.
A sensitive first order derivative method has
been developed and validated for the determination of
Loperamide hydrochloridein formulations using
Methanol: HCL as a solvent. The drug showed
maximum absorbance at 259 nm and amplitude
measured in the range of 257 nm-275 nm. The drug
obeyed linearity in the range of 400-1400 μg/mL. The
present method was validated as per International
Conference on Harmonization guidelines. Percent
recovery for Loperamide hydrochloride was obtained in
the range of 97.90 - 99.99 % , indicates accuracy and %
RSD < 2, indicates precision of the method. The results
showed that the proposed method is suitable, precise,
accurate and rapid for determination of Loperamide
hydrochloride in bulk, its tablet dosage forms.
