First Order Derivative Spectrophotometric Method for Estimation of Loperamide Hydrochloride in Bulk and Pharmaceutical Dosage Form


Authors : Pradnya Patil; Vaishali Rakibe; Tejal P. Patil; Dr. Rajanikant. T. Kakde; Jadhav M. M.

Volume/Issue : Volume 9 - 2024, Issue 1 - January

Google Scholar : http://tinyurl.com/bde8aed9

Scribd : http://tinyurl.com/2v9dfum5

DOI : https://doi.org/10.5281/zenodo.10518454

Abstract : A sensitive first order derivative method has been developed and validated for the determination of Loperamide hydrochloridein formulations using Methanol: HCL as a solvent. The drug showed maximum absorbance at 259 nm and amplitude measured in the range of 257 nm-275 nm. The drug obeyed linearity in the range of 400-1400 μg/mL. The present method was validated as per International Conference on Harmonization guidelines. Percent recovery for Loperamide hydrochloride was obtained in the range of 97.90 - 99.99 % , indicates accuracy and % RSD < 2, indicates precision of the method. The results showed that the proposed method is suitable, precise, accurate and rapid for determination of Loperamide hydrochloride in bulk, its tablet dosage forms.

A sensitive first order derivative method has been developed and validated for the determination of Loperamide hydrochloridein formulations using Methanol: HCL as a solvent. The drug showed maximum absorbance at 259 nm and amplitude measured in the range of 257 nm-275 nm. The drug obeyed linearity in the range of 400-1400 μg/mL. The present method was validated as per International Conference on Harmonization guidelines. Percent recovery for Loperamide hydrochloride was obtained in the range of 97.90 - 99.99 % , indicates accuracy and % RSD < 2, indicates precision of the method. The results showed that the proposed method is suitable, precise, accurate and rapid for determination of Loperamide hydrochloride in bulk, its tablet dosage forms.

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