Authors : Sarita; Sanjeev Kumar; Pushpendra Kannojia; Shailendra Kumar Verma; Prashant Kumar Sharma

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/yz8xvunp

Scribd : https://tinyurl.com/mr5dkr83

DOI : https://doi.org/10.38124/ijisrt/26apr689

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Atopic dermatitis (AD) affects about 20% of people worldwide, including children, and its incidence is rising dramatically. The pathophysiology of AD is thought to be largely influenced by complex interactions between abnormalities in the function of the epidermal barrier, the environment, infectious agents, and immunological deficiencies. Ethosomes are soft, elastic lipid vesicles composed of phospholipids, alcohol, poly glycol, and water. The presence of alcohol plays a crucial role by acting as a penetration enhancer, thereby increasing skin permeability. A key characteristic of ethosomes is their high deformability, which allows them to pass through the skin in an intact form and deliver drug molecules more effectively in terms of both depth of penetration and amount transported. These vesicular systems are capable of facilitating efficient intracellular delivery of hydrophilic, lipophilic, and amphiphilic drugs. Ethosomes typically range in size from a few tens of nanometers to several microns. Ethosomes have garnered a lot of scientific interest because of their special qualities, which include improved drug delivery effectiveness, increased drug entrapment capacity, and improved skin penetration.The advantages, disadvantages, composition, preparation techniques, characterisation, penetration mechanism, and therapeutic applications of ethosomal drug delivery systems are all covered in this review. Ethosomal systems have been the focus of ongoing research, which indicates that these carriers could be effective drug delivery vehicles in the form of gels, patches, and creams when combined with penetration enhancers. To improve the stability of the ethosomal system, however, more extensive research is needed. The synthesis and characterization of ethosomal gel drug delivery is the aim of this review.

Keywords : Atopic Dermatitis, Ethosomes, Transdermal Drug Delivery, Skin Penetration, Phospholipids.

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