Formulation and Evaluation of Antimicrobial Activity of Suppositories by Using Cassia Fistula


Authors : Dr. M. Sakthivel; Dr. S. Mohamed Halith; A. Afrinbanu; S. Agalya; C. Ahalyamohan; S. Akash; S. Amina Banu

Volume/Issue : Volume 11 - 2026, Issue 2 - February


Google Scholar : https://tinyurl.com/53hetuy5

Scribd : https://tinyurl.com/2w57ecym

DOI : https://doi.org/10.38124/ijisrt/26feb869

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : This study evaluates herbal suppositories made from Cassia fistula (Golden Shower) extracts, which have inherent antibacterial characteristics. We created four formulations (F1, F2, F3, and F4) that combine gelatin, glycerin, and water with an ethanolic extract of plant flowers or leaves. The major goal was to evaluate the effectiveness of these suppositories against common infections by agar well diffusion and disc diffusion methods. The herbal suppositories demonstrated broadspectrum antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Candida albicans.

References :

  1. World Health Organization. (2003). Traditional Medicine: Report by the Secretariat. Fifty-sixth World Health Assembly, Provisional agenda item 14.10 (A56/18). Geneva: WHO. Available at: https://iris.who.int/handle/10665/78244
  2. Edson, B., & Lazarus, J. (1991). Semisolids. In L. Lachman, H. A. Liberman, & J. L. Kanig (Eds.), The Theory and Practice of Industrial Pharmacy (pp. 534-563). Varghese Publishing House."
  3. Liebermann HA, Rieger MM, Banker GS pharmaceuticals dosage forms: disperse system, 2nd edition Volume 3, Marcel Dekker: New York 1989, PP. 473-511.
  4. Antony S ham Robert W Buckhiet, Jr. Designing and Developing Suppository Formulation for anti-HIV drug Delivery 2017
  5. Aiache Jin, Renoux R, Fistre D. editors’ History of the suppository form.JR. porous publisher; Barcelona farm. Spain; 1984.
  6. Aman Kumar, Arindam Kolay, Gujwal      Havelikar, Modern Aspects of         suppository review August 2023 Europe Journal of pharmaceutical research 3(4) 23-29.
  7. Datiles, Marianne Jennifer, Acevedo. Rodriguez, pedro (2022). Cassia fistula in vasive Species Compendium. CABI Compendium 11434 CABI
  8. Sinhala botany Website. (Sinhala) Department of National Botanic Gardens. (2022). Taxonomy and Distribution of Cassia fistula. Retrieved from http://www.botanicgardens.gov.lk/
  9. Purgative pole. Sebastian. Ayurvedic Medicine... Pole, S. (2012). Ayurvedic Medicine: The Principles of Traditional Practice. London: Singing Dragon. p. 129. ISBN 978-1-84819-113-6.
  10. Awoyinka, O.A., Balogun, I. O., & Ogunnowo, A. A, (2007). Phytochemical screening and in vitro bioactivity of Cnidoscolus aconitifolius (Euphorbiaceae). Journal of medicinal plants research, 1(3),63-65.

This study evaluates herbal suppositories made from Cassia fistula (Golden Shower) extracts, which have inherent antibacterial characteristics. We created four formulations (F1, F2, F3, and F4) that combine gelatin, glycerin, and water with an ethanolic extract of plant flowers or leaves. The major goal was to evaluate the effectiveness of these suppositories against common infections by agar well diffusion and disc diffusion methods. The herbal suppositories demonstrated broadspectrum antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Candida albicans.

Paper Submission Last Date
31 - March - 2026

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