Formulation and Evaluation of Controlled Release Tablet Using Thyme and Rosemary for Osteoporosis


Authors : Mansi Sharma

Volume/Issue : Volume 9 - 2024, Issue 9 - September


Google Scholar : https://tinyurl.com/bdemazy7

Scribd : https://tinyurl.com/27jvyvrd

DOI : https://doi.org/10.38124/ijisrt/IJISRT24SEP1199

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Osteoporosis is a common public health problem which currently affected millions of people worldwide. Osteoporosis is mainly associated with Ovarian hormone deficiency following menopause is till now a most common reason of age-related bone loss. There are tablets that are available in the market, which shows the side effect such as nausea, heart burn, gastric problem after the continuous use of medicine. These side effects led to the avoidance of such medicine. Using herbal plant such as thyme and rosemary as an alternative of those drug will help to reduce these effects. Hence, selected to develop a Controlled Release Tablet of Rosemary and Thyme. Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing. Developing the tablet using thyme and rosemary in the form of controlled release drug will help to prolonged the effect of the medicine. As precision of dosing, to improve the bioavailability of the drug and to maintain the constant level of drug in the plasma become important to provide the long-term effect to the patient. It will also provide the patience compliance as well as prolonged the effect of drug in the patient’s body.

Keywords : Osteoporosis, Controlled-Release Tablets, Rosemary, Thyme And Dosage Forms.

References :

  1. Elbahnasawy, A. S., Valeeva, E. R., El-Sayed, E. M., & Rakhimov, I. I. (2019). The impact of thyme and Rosemary on prevention of osteoporosis in rats. Journal of Nutrition and Metabolism, 2019, 1431384.
  2. Hassan, R., & Hassan, D. R. (n.d.). Preventive effect of herbs Rosemary and Thyme (Salvia Rosmarinus and Thymus Vulgaris) on ad: aluse ss bxe lUo so. Rats Female in Osteoporosis Jan, 9, 28–44.
  3. Trzaskowska, M., Vivcharenko, V., Kazimierczak, P., Wolczyk, A., & Przekora, A. (2023). In vitro screening studies on eight commercial essential oils-derived compounds to identify promising natural agents for the prevention of osteoporosis. Biomedicines, 11(4).
  4. Evelyn, S. S., & Chitra, V. (2019). Medicinal plants for the treatment of postmenopausal osteoporosis. Biomedical & Pharmacology Journal, 12(3).
  5. Mahant, M., Besh, S. B., Kanojiya, D., Sajan, C., Rajput, H., & Maheshwari, R. A. (2023). Herbal Remedies for Osteoporosis. Journal of Natural Remedies, 1373–1383.
  6. Putnam, S. E., Scutt, A. M., Bicknell, K., Priestley, C. M., & Williamson, E. M. (2007). Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health. Phytotherapy Research: PTR, 21(2), 99–112.
  7. Alkazzaz, A. M., Abu-Raghif, A. R., & Fadheel, Q. J. (n.d.). A Comparative Study of the Effect of Sodium Alendronate plus Thyme and Sodium Alendronate alone in Treatment of Postmenopausal Women with Osteoporosis. Age (Year), 60(1.7), 57–95.
  8. Banu, J., Varela, E., & Fernandes, G. (2012). Alternative therapies for the prevention and treatment of osteoporosis. Nutrition Reviews, 70(1), 22–40.
  9. Hiremath, P. S., & Saha, R. N. (2008). Controlled release hydrophilic matrix tablet formulations of isoniazid: design and in vitro studies. AAPS PharmSciTech, 9(4), 1171–1178.
  10. Mohamed, A. I., Abd-Motagaly, A. M., Ahmed, O. A., Amin, S., & Ali, M. (2017). Investigation of Drug-Polymer Compatibility Using Chemometric-Assisted UVSpectrophotometry. Pharmaceutics, 9(1).
  11. Almeida Moreira Leal, L. K. (2017). Validation of A high performance liquid chromatography method to quantify thymol in nanocapsules of bioactive essential oil from Lippia sidoides. International Journal of Complementary & Alternative Medicine, 10(2).
  12. Adepu, S., & Ramakrishna, S. (2021). Controlled drug delivery systems: Current status and future directions. Molecules (Basel, Switzerland), 26(19), 5905.
  13. Jadav, M., Pooja, D., Adams, D. J., & Kulhari, H. (2023). Advances in xanthan gum-based systems for the delivery of therapeutic agents. Pharmaceutics, 15(2), 402.
  14. Wasilewska, K., & Winnicka, K. (2019). Ethylcellulose-A pharmaceutical excipient with multidirectional application in drug dosage forms development. Materials, 12(20), 3386.
  15. Arora, G., Malik, K., Singh, I., Arora, S., & Rana, V. (2011). Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. Journal of Advanced Pharmaceutical Technology & Research, 2(3), 163–169.
  16. Shashank, M., Patil, R., Ramu, P. S., Shirahatti, C., & Raghavendra, G. (n.d.). A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn. Heliyon, 7.
  17. Rajendar, M., & Saraswathi, B. (n.d.). Formulation and Evaluation of Fluvoxamine controlled release tablet. Int J Curr Pharm Res, 7, 47–51.
  18. Hebbink, G. A., & Dickhoff, B. H. J. (2019). Application of lactose in the pharmaceutical industry. In Lactose (pp. 175–229). Elsevier.
  19. O’Callaghan, T. F., Sugrue, I., Hill, C., Ross, R. P., & Stanton, C. (2019). Nutritional aspects of raw milk. In Raw Milk (pp. 127–148). Elsevier.
  20. Hiremath, P., Nuguru, K., & Agrahari, V. (2019). Material attributes and their impact on wet granulation process performance. In Handbook of Pharmaceutical Wet Granulation (pp. 263–315). Elsevier.
  21. Namdeo, J. (2013). World journal of pharmacy and pharmaceutical sciences. 2, 4639–4660.
  22. Walid, Y. (2022). Optimizing ethanol extraction of rosemary leaves and their biological evaluations. Journal of Exploratory Research in Pharmacology.
  23. Yeddes, W., Majdi, H., Gadhoumi, H., Affes, T. G., Mohamed, S. N., Aidi Wannes, W., & Saidani-Tounsi, M. (2022). Optimizing ethanol extraction of Rosemary leaves and their biological evaluations. Journal of Exploratory Research in Pharmacology, 7(2), 85–94.
  24. Narasaiah, V. L. (2010). Stability studies of formulated controlled release Aceclofenac tablets. International Journal of Chemical Sciences, 81, 405–414.
  25. Jirapornchai, S. (2023). Application of microwave-assisted drying to shorten granules drying process for the preparation of thunbergia laurifolia lindl. Leaf tablets. Trends in Science, 20(5).
  26. Jaume, S. (2014). Quality by design approach to understand the physiochemical phenomena involved in controlled release of captopril SR matrix tablets. International Journal of Pharmaceuticals, 477(1).
  27. Padmaa, P. (2018). Release kinetics concepts and applications. Internation Journal of Pharmaceutical Research and Technology, 10.
  28. Ali, R., & Maedeh, D. (n.d.). UV Spectrophotometric method development and Validation for the Quantitative measurement of Rosmarinic Acid. Der Pharma Chemica, 2023(3), 1–4.
  29. Mohapatra, S., Kumar, P. A., Aggarwal, A., Iqubal, A., Mirza, M. A., & Iqbal, Z. (2024). Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis. Phytotherapy Research: PTR, 38(6), 2728–2763.
  30. Dhiman, S., Chopra, B., Dhingra, A. K., Grewal, A. S., Kriplani, P., Deswal, G., Dass, R., & Guarve, K. (2024). Cultivating bone health: Exploring medicinal plants and bioactive compounds for osteoporosis treatment. The Natural Products Journal, 14(6).
  31. Ozdal, T., Tomas, M., Toydemir, G., Kamiloglu, S., & Capanoglu, E. (2021). Introduction to nutraceuticals, medicinal foods, and herbs. In Aromatic Herbs in Food (pp. 1–34). Elsevier.
  32. Maring, M., Balaji, C., Komala, M., Nandi, S., Latha, S., & Raghavendran, H. B. (2024). Aromatic plants as potential resources to combat osteoarthritis. Combinatorial Chemistry & High Throughput Screening, 27(10), 1434–1465.
  33. Ozdal, T., Tomas, M., Toydemir, G., Kamiloglu, S., & Capanoglu, E. (2021). Introduction to nutraceuticals, medicinal foods, and herbs. In Aromatic Herbs in Food (pp. 1–34). Elsevier.
  34. Price, L. (2021). Traditional Use, Research and Properties. Aromatherapy for Health Professionals Revised Reprint E-Book: Aromatherapy for Health Professionals Revised Reprint E-Book. 57.
  35. Riar, C. S., & Panesar, P. S. (2024). Bioactive Compounds and Nutraceuticals: Classification, Potential Sources, and Application Status. In Bioactive Compounds and Nutraceuticals from Dairy, Marine, and Nonconventional Sources (pp. 3–60). Apple Academic Press.
  36. Lippert, A., & Renner, B. (2022). Herb-drug interaction in inflammatory diseases: Review of phytomedicine and herbal supplements. Journal of Clinical Medicine, 11(6), 1567.
  37. He, J.-B., Chen, M.-H., & Lin, D.-K. (2017). New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis. Archives of Osteoporosis, 12(1).
  38. Mühlbauer, R. C., Lozano, A., Palacio, S., Reinli, A., & Felix, R. (2003). Common herbs, essential oils, and monoterpenes potently modulate bone metabolism. Bone, 32(4), 372–380.
  39. Sienkiewicz, M., Łysakowska, M., Kowalczyk, E., Szymańska, G., Kochan, E., Krukowska, J., Olszewski, J., & Zielińska-Bliźniewska, H. (2017). The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria. Burns: Journal of the International Society for Burn Injuries, 43(2), 310–317.
  40. Sancheti, G., & Goyal, P. K. (2006). Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice. Phytotherapy Research: PTR, 20(11), 981–986

Osteoporosis is a common public health problem which currently affected millions of people worldwide. Osteoporosis is mainly associated with Ovarian hormone deficiency following menopause is till now a most common reason of age-related bone loss. There are tablets that are available in the market, which shows the side effect such as nausea, heart burn, gastric problem after the continuous use of medicine. These side effects led to the avoidance of such medicine. Using herbal plant such as thyme and rosemary as an alternative of those drug will help to reduce these effects. Hence, selected to develop a Controlled Release Tablet of Rosemary and Thyme. Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing. Developing the tablet using thyme and rosemary in the form of controlled release drug will help to prolonged the effect of the medicine. As precision of dosing, to improve the bioavailability of the drug and to maintain the constant level of drug in the plasma become important to provide the long-term effect to the patient. It will also provide the patience compliance as well as prolonged the effect of drug in the patient’s body.

Keywords : Osteoporosis, Controlled-Release Tablets, Rosemary, Thyme And Dosage Forms.

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe