Authors :
Prachi Shrivastava; Pura Akang; Nikita Savita
Volume/Issue :
Volume 9 - 2024, Issue 10 - October
Google Scholar :
https://tinyurl.com/3nk6ycwx
Scribd :
https://tinyurl.com/3ate8ds7
DOI :
https://doi.org/10.5281/zenodo.14355282
Abstract :
The formulation aimed to synergize the
benefits of both turmeric and caffeine in a single tablet
and targeting condition on inflammation, pain.
Osteoarthritis is a chronic joint disease where cartilage
wears down, leading to bone-on-bone contact, pain,
limited mobility, stiffness. Turmeric and caffeine have
anti-inflammatory and analgesic properties by
combination it helps in osteoarthritis. Turmeric is rich in
curcumin it exhibits potent anti-inflammatory and also
analgesic properties, while caffeine enhance pain relief
and serves as a stimulant also improve mental alertness ,
focus and increase the curcumin bioavailability
.Combination of these natural ingredient into a single
tablet could provide a synergistic effect and improving
efficacy and patient compliance.
The combination significantly reduce pain and
improve joint function in osteoarthritis patients the dual
action formulation exhibited potential effects for
conditions such as chronic inflammation and cognitive
decline .The turmeric and caffeine tablet presents a
combined therapeutics effects in a single dosage form for
osteoarthritis offering both symptomatic relief and
potential long term benefits in managing the
osteoarthritis condition the tablet was designed a direct
compression method to obtained a optimal bioavailability
References :
- Mukne A, Momin M, Betkar P and Joshi V: Standardization of herbal biomolecules. In Herbal Biomolecules in Healthcare Applications 2022; 643-667.
- Joshi AA, Duriez X., 2004. Added Functionality Excipients: an answer to challenging formulations. Pharmaceutical Technology suppl, pp. 12-19.
- Marshall, K., and E. M. Rudnic. 1990. Tablet dosage forms. p. 355-425. In G. S. Banker and C.T. Rhodes (eds) Modern Pharmaceutics 2nd edition, Marcel Dekker, New York.
- Lund W. 1994. The Pharmaceutical Codex, Principles and Practice of Pharmaceutics.12 Edition, London, pp.2-30.
- Alam, K., Shareef, H., & Bushra, R. (2013). Formulation development & evaluation of caffeine tablets (200 mg) by direct compression. International Journal of Drug Development and Research, 5 no3
- Martino PD, Joiris E and Martelli S (2004). Particle interaction of lubricated or un lubricated binary mixtures according to their particle size and densification mechanism II. Farmaco., 59(9): 747-758
- Katz, D. L., & Williams, A. L. (2013). Herbal medicine: A comprehensive review. Journal of Alternative and Complementary Medicine, 19(6), 531-538
- Braun, L., & Cohen, M. (2015). Herbs and natural supplements: An evidence-based guide. Elsevier.
- Eisenberg, D. M., et al. (2016). Trends in alternative medicine use in the United States, 1990-1997. Journal of the American Medical Association, 280(18), 1569-1575.
- Kumar et al. (2015). Herbal tablets: A study on bioavailability. Journal of Pharmacy and Pharmacology, 67(8), 1111-1121.
- Singh et al. (2013). Herbal medicine: A review. Journal of Medicinal Food, 16(10), 913-922.
- Grzanna et al. (2014). Herbal extracts as immunomodulators. Journal of Medicinal Food, 17(10), 1032-1042.
- Mukherjee et al. (2019). Antioxidant activity of herbal extracts. Journal of Food Science and Technology, 56(4), 2240-2248.
- Kim et al. (2018). Herbal tablets: Enhanced bioavailability. Journal of Ethnopharmacology, 211, 345-353.
- Srivastava et al. (2017). Hepatoprotective effects of herbal extracts. Journal of Ethnopharmacology, 198, 101-108.
- Choudhary et al. (2018). Herbal medicine for hormonal balance. Journal of Alternative and Complementary Medicine, 24(3), 236-242.
- Daily et al. (2016). Efficacy of turmeric extract and curcumin for alleviating the symptoms of joint arthritis. Journal of Medicinal Food, 19(8), 713-721.
- Blumenthal et al. (2000). Herbal Medicine: Expanded Commission E Monographs. American Botanical Council.
- Kumar et al. (2014). Ginkgo biloba: A review of its' anti-inflammatory and antioxidant properties. Journal of Pharmacy and Pharmacology, 66(8), 1081-1094.
- Cohen, M. M. (2014). Tulsi: A review of its medicinal properties. Journal of Alternative and Complementary Medicine, 20(3), 145-155.
- Andrade, C., et al. (2012). Ashwagandha for anxiety disorders. Journal of Clinical Psychopharmacology, 32(3), 295-300.
- Taibi et al. (2018). Valerian root for sleep disorders. Journal of Clinical Sleep Medicine, 14(2), 247-253.
- Ryan et al. (2012). Ginger for nausea and vomiting. Journal of Alternative and Complementary Medicine, 18(10), 1014-1021.
- Chandran et al. (2012). Rhizome of Curcuma longa L. (turmeric) and its active compound curcumin as potential therapeutic agents for rheumatoid arthritis. Journal of Pharmacy and Pharmacology, 64(8), 1091-1099.
- Harris et al. (2007). Omega-3 fatty acids and cardiovascular disease. Journal of Cardiovascular Medicine, 8(1), 84-91.
- Hernandez-Camacho et al. (2018). Coenzyme Q10 supplementation in humans. Nutrients, 10(11), 1617.
- Shi et al. (2017). Grape seed proanthocyanidins and cardiovascular health. Journal of Medicinal Food, 20(10), 1039-1046.
- Kumar et al. (2018). Neem: A review of its' medicinal properties. Journal of Pharmacy and Pharmacology, 70(8), 1081-1094.
- Hernandez-Camacho et al. (2018). Aloe vera: A review of its' hydrating and soothing properties. Journal of Pharmacy and Pharmacology, 70(8), 1095-1104
- Bagchi et al. (2003). Neem: A review of its' medicinal properties. Journal of Pharmacy and Pharmacology, 55(8), 1135-1142.
- WHO (2019). WHO Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines.
- Weinmann et al. (2010). Effects of Ginkgo biloba on cognitive function. Cochrane Database of Systematic Reviews, 2010(1), CD003120.
- Gengler et al. (2000). St. John's Wort for depression. Cochrane Database of Systematic Reviews, 2000(2), CD000448.
- Aggarwal BB, Sundaram C & Malani N, Curcumin, In: The Indian Solid Gold, edited by Aggarwal BB, Surh Yj & Shishodia, (springer, New York), 2007, 8.
- Sukandar, E. Y., Adnyana, I. K., & Nurfitria, R. S. (2015). Antioxidant potential of garlic and turmeric mixture-A Traditional Indonesian formulation. Indian Journal of Traditional Knowledge, 14(4), 632-636.
- Patle, S., Mujariya, R. Z., & Singh, M. (2023). Formulation and Evaluation of Herbal Tablet of Curcumin for Anticancer Activity. International Journal of Creative Research Thoughts (IJCRT), 11(8).
- Bhowmik, D., Chiranjib, K. P. S. Kumar, M. Chandira, & B. Jayakar. (2009). Turmeric: A Herbal and Traditional Medicine. Archives of Applied Science Research, 1(2), 86-108.
- Grzanna et al. (2014). Curcumin inhibits inflammatory mediators. Journal of Medicinal Food, 17(10), 1032-1042.
- Suresh et al. (2010). Antioxidant activity of curcumin. Journal of Food Science and Technology, 47(4), 391-396.
- Shoba et al. (1998). Influence of piperine on the pharmacokinetics of curcumin. Planta Medica, 64(4), 353-356
- Daily, J. et al. (2016). Efficacy of turmeric extract and curcumin for alleviating the symptoms of joint arthritis. Journal of Medicinal Food, 19(8), 713-721.
- Kumar et al. (2015). Curcumin: A review of its' anti-cancer properties. Journal of Pharmacy and Pharmacology, 67(8), 1111-1121.
- Kumar et al. (2018). Curcumin: A review of its anti-inflammatory and antioxidant properties. Journal of Medicinal Food, 21(1), 1-13.
- Jurenka et al. (2009). Anti-inflammatory properties of curcumin. Journal of Alternative and Complementary Medicine, 15(9), 965-973.
- Moon et al. (2011). Curcumin attenuates inflammatory responses in collagen-induced arthritis in rats. Journal of Pharmacy and Pharmacology, 63(8), 1064-1073.
- Zhang et al. (2013). Curcumin ameliorates dextran sulfate sodium-induced colitis in rats. Journal of Pharmacology and Experimental Therapeutics, 346(2), 279-88.
- Ali M. Text book of Pharmacognosy, 2008, CRC Press, India.
- Nimbhorkar, R., Rasane, P., & Singh, J. (2021). Caffeine alternatives: Searching a herbal solution. The Pharma Innovation Journal, 10(5), 256-264.
- Attipoe S, Leggit J, Deuster PA. Caffeine content in popular energy drinks and energy shots. Military Medicine 2016;181(9):1016–1020. https://doi.org/10.7205/MILMED-D-15-00459.
- Knight CA, Knight I, Mitchell DC, Zepp JE. Beverage caffeine intake in US consumers and subpopulations of interest: Estimates from the Share of Intake Panel survey. Food and Chemical Toxicology 2004;42(12):1923-1930.
- Fredholm, B. B., et al. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews, 51(1), 83-133.
- Sawynok, J. (2011). Caffeine and pain. Progress in Neurobiology, 95(2), 169-184.
- Colloca, L., et al. (2017). Caffeine and pain: A systematic review. Journal of Pain Research, 10, 1275-1285.
- Bardin, L., et al. (2017). Caffeine and pain modulation. European Journal of Pharmacology, 812, 123-132.
- Singh et al. (2020). Curcumin: A review of its anti-inflammatory and antioxidant properties in the treatment of osteoarthritis. Journal of Medicinal Food, 23(10), 1039-1046.
- Ryu, J. et al. (2016). Curcumin inhibits osteoarthritis by suppressing NF-κB activation. Journal of Orthopaedic Research, 34(5), 931-938.
- Kim, J. et al. (2018). Curcumin enhances chondrocyte viability and inhibits inflammation in osteoarthritis. Inflammation Research, 67(5), 431-440.
- Liu, X., et al. (2017). Caffeine inhibits osteoarthritis by suppressing chondrocyte apoptosis and inflammation. International Journal of Molecular Medicine, 40(3), 667–674.
- Katz, D. L., et al. (2012). Caffeine and coffee consumption in relation to the risk of osteoarthritis. Journal of Rheumatology, 39(11), 2204–2212.
- Lee et al. (2017). Caffeine alleviates pain and inflammation in a rat model of osteoarthritis. European Journal of Pharmacology, 794, 111-118.
- Manasa, P. S. L., Kamble, A. D., & Chilakamarthi, U. (2023). Various extraction techniques of curcumin ─A comprehensive review. ACS Omega, 8(38), 34868-34878.
- Wang et al. (2012). Curcumin protects against lipopolysaccharide-induced acute lung injury in rats. European Journal of Pharmacology, 685(1-3), 296-302.
- Thokale, A. G., Tajir, A., Mohite, V., & Patil, P. (2022). Extraction of Caffeine from Tea Powder: A Review. Journal of Emerging Technologies and Innovative Research (JETIR), 9(4).
- Patel, V. J., Shah, S. A., & Patel, Y. (2023). Formulation and Evaluation of Polyherbal Tablet. International Journal of Research and Analytical Reviews (IJRAR), 10(2).
- Tomar, N., Tomar, M., Gulati, N., & Nagaich, U. (2012). Formulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach. Der Pharmacia Lettre, 4(5), 1490-1494.
- Mankar, S. D., Shaikh, S. B., & Tamboli, A. A. (2020). Formulation of Herbal Tablet with the help of Tulsi and Turmeric Extract which Showing Antimicrobial Activity. Research Journal of Science and Technology, 12(1).
The formulation aimed to synergize the
benefits of both turmeric and caffeine in a single tablet
and targeting condition on inflammation, pain.
Osteoarthritis is a chronic joint disease where cartilage
wears down, leading to bone-on-bone contact, pain,
limited mobility, stiffness. Turmeric and caffeine have
anti-inflammatory and analgesic properties by
combination it helps in osteoarthritis. Turmeric is rich in
curcumin it exhibits potent anti-inflammatory and also
analgesic properties, while caffeine enhance pain relief
and serves as a stimulant also improve mental alertness ,
focus and increase the curcumin bioavailability
.Combination of these natural ingredient into a single
tablet could provide a synergistic effect and improving
efficacy and patient compliance.
The combination significantly reduce pain and
improve joint function in osteoarthritis patients the dual
action formulation exhibited potential effects for
conditions such as chronic inflammation and cognitive
decline .The turmeric and caffeine tablet presents a
combined therapeutics effects in a single dosage form for
osteoarthritis offering both symptomatic relief and
potential long term benefits in managing the
osteoarthritis condition the tablet was designed a direct
compression method to obtained a optimal bioavailability