Formulation and Evaluation of Nail Lacquer Containing Anti fungal Griseofulvin for the Treatment of Onychomycosis

Authors : Anurag Srivastava; Sangeeta Singh; Aswani Kumar

Volume/Issue : Volume 6 - 2021, Issue 12 - December

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Onychomycosis is a fungus that infects the human nail and affects 19% of the world's population. It is responsible for half of all nail problems in diabetic and older individuals. Dermatophytes are the most frequent cause of onychomycosis, although yeasts and candida may also cause it, because the illness is persistent, difficult to eliminate, and prone to recurrence, it is tough to control. The diseased nails are unsightly, discoloured, thicker, and dystrophic, which has a detrimental effect on the patient's social life. Topical therapy has been shown to be a viable alternative to systemic administration in the treatment of onychomycosis, since it is capable of overcoming many of the constraints of systemic administration and targeting the medication at its site of action with minimal interactions and side effects. Limited permeability of the medication through the nail plate and blood supply in the afflicted region may result in sub-therapeutic concentrations, which may be addressed by applying the drug topically. Furthermore, since most commonly used formulations are easily removed by rubbing or washing, they are not particularly suited to the nail. To get over these obstacles, ungual delivery (drug administration across the nail plate) may be used. Transungual drug delivery is a method for transporting drugs through the nail to provide targeted medication administration in the treatment of nail disorders. “Trans” means “through”, and “unguis” means “nails” in the word transungual [10]. Because of its superior adherence and localised action, which offers less systemic adverse effects, the transungual medication delivery method is considered to be highly useful in managing nail diseases. Nail lacquers seem to be commercially preferred for a variety of reasons, including their long residence duration on the nail plate and low wash-off or loss resistance. Nail lacquers are also generally accepted by patients and simple to apply, in addition to preventing tranonychial water loss and allowing for prolonged medication diffusion through concentration gradients.


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