Acute pharyngitis is a highly prevalent community-acquired infection, characterized by a sore throat. Oral throat spray preparations have several benefits compared to standard topical preparations, it gives a uniform drug distribution and dose, increased bioavailability, and lower incidence of irritation. Throat spray formulation comprises polymers and excipients that improve formulation characteristics and enhance the stability of active substances. There is evidence that natural product has the potential to suppress sore throat infection. The present study aimed to develop an oral herbal throat spray containing Triphala and Liquorice. Four batches (F1 to F4) of spray solution were formulated with selected chief ingredient, eudragit EPO as polymer and propylene glycol as excipients, and evaluated. The evaluation parameter such as pH, spray pattern, spray angle, particle size, and evaporation time was performed to find out the difference between the formulation. The results indicated that formulation(F2) was hazy and slightly yellow in appearance, stable at pH 7, had less evaporation time, spray particle was spherical and uniform in size, spray angle is 75.42º, droplet size is 10µm, and contain a total of 88 percent of drug content. The spray is convenient to apply so, improves patient compliance and acceptance.

Keywords : Herbal Throat Spray, Triphala, Liquorice, Eudragit EPO.